Results 161 to 170 of about 5,630 (236)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, EarlyView.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Inactive "Ghost" Cells Do Not Affect Motility and Long-Range Electron Transport in Filamentous Cable Bacteria. [PDF]

Environ Microbiol
van Dijk JR, Geelhoed JS, Geerlings N, Choyikutty JA, Boschker HTS, Verbruggen E, Meysman FJR.   +6 more
europepmc   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

Variable species establishment in response to microhabitat indicates different likelihoods of climate‐driven range shifts

Ecography, EarlyView.
Climate change is causing geographic range shifts globally, and understanding the factors that influence species' range expansions is crucial for predicting future biodiversity changes. A common, yet untested, assumption in forecasting approaches is that species will shift beyond current range edges into new habitats as they become macroclimatically ...
Nathalie Isabelle Chardon, Lauren McBurnie, Katie J. A. Goodwin, Kavya Pradhan, Janneke Hille Ris Lambers, Amy L. Angert   +5 more
wiley   +1 more source

Hydrated cable bacteria exhibit protonic conductivity over long distances. [PDF]

Proc Natl Acad Sci U S A
Lusk BG, Morgan S, Mulvaney SP, Blue B, LaGasse SW, Cress CD, Bjerg JT, Lee WK, Eddie BJ, Robinson JT.   +9 more
europepmc   +1 more source

Prevalence of Post‐Operative Complications in Autotransplanted Teeth: A Long‐Term Retrospective Cohort

Dental Traumatology, EarlyView.
ABSTRACT Background/Aims To evaluate the prevalence and timing of post‐operative complications following tooth autotransplantation, identify factors associated with earlier diagnosis, and report long‐term survival and success rates. Materials and Methods A single‐centre retrospective cohort study was conducted at a Czech university dental clinic (2003 ...
Juraj Marton, Radovan Žižka, Linda Kučerová, Přemysl Krejčí, Martin Starosta, Zdeněk Pokorný   +5 more
wiley   +1 more source

Using Eye Lens Stable Isotopes to Identify the Rearing Origin of Fall Age‐0 Walleye (Sander vitreus)

Fisheries Management and Ecology, EarlyView.
ABSTRACT Isotope values in fish eye lenses may be useful in differentiating rearing origins. We compared eye lens isotopic values of fall fingerling age‐0 walleye (Sander vitreus) reared in a hatchery pond, a recirculating aquaculture system (RAS), and a natural lake. Using 10 fish per rearing source, we delaminated layers from one eye lens per fish to
Justin M. Sturtz, Benjamin J. Schall, Matthew J. Ward, Cody E. Treft, Steven R. Chipps, Christopher A. Cheek   +5 more
wiley   +1 more source

Effectiveness of Toothbrush Containing Solar Cells and Titanium Dioxide Rod on Plaque Reduction During Caregiver‐Performed Toothbrushing—Randomised Crossover Clinical Trial

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives This study was conducted to assess the effectiveness of a toothbrush containing solar cells and a titanium dioxide electrode (TiO2 toothbrush) compared with a normal toothbrush for removing plaque during caregiver‐performed oral hygiene care for elderly residents in nursing homes who require care. Methods A randomised, double‐blind,
Jumpei Murakami, Mai Niida
wiley   +1 more source

Machine Learning‐Based Prediction of Dental Caries in 12‐Year‐Old Adolescents: A Nationwide Cross‐Sectional Study in Korea

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective We aimed to develop and evaluate machine learning models to support population‐level risk stratification for dental caries in the permanent dentition of 12‐year‐old Korean children and to visualise the relative importance of key predictors.
Gahyun Cho, Hae‐Young Kim, Ki‐Bong Choi, Sunmi Song, Junesun Kim   +4 more
wiley   +1 more source