Results 191 to 200 of about 991,759 (242)

Surgical management of a penetrating cardiac foreign body causing tamponade in a dog: case report

Australian Veterinary Journal, EarlyView.
Background Penetrating cardiac foreign bodies are rare in dogs but can result in life‐threatening complications, including pericardial effusion and cardiac tamponade. Prompt diagnosis, emergency stabilization, and definitive surgical management are essential to achieve a favorable outcome.
RB Abibe, SC Rahal, GB Mazzali, FJT Neto, VM d V Machado, CVS Brandão   +5 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

Rearing Istocheta aldrichi (Diptera: Tachinidae) From Field‐Collected Japanese Beetles (Popillia japonica): 2. Methods to Improve Overwintering, Adult Emergence and Longevity

Entomologia Experimentalis et Applicata, EarlyView.
Successful rearing of Istocheta aldrichi, a tachinid parasitoid of invasive Japanese beetle, depended on conditions before, during, and after overwintering. Longer cold exposure increased adult emergence and accelerated post‐diapause development. Early transfer of puparia to cool conditions improved survival, while spring temperature manipulation ...
Paul K. Abram, Simon Legault, Josée Doyon, Victoria Makovetski, Jacob H. Miall, Jean‐Philippe Parent, Jason Thiessen, Jacques Brodeur   +7 more
wiley   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

The FEBS Journal, EarlyView.
Ferredoxins are small FeS cluster‐containing proteins that play a central role in distributing electrons within the cell. The cyanobacterium Synechocystis sp. PCC 6803 contains several ferredoxin isoforms and their biophysical properties (UV/Vis and EPR spectra, Em potential), expression patterns, and interactions with the electron donors photosystem I
Marko Boehm, Drazenka Svedruzic, Carolyn E. Lubner, Jens Appel, David W. Mulder, Effie C. Kisgeropoulos, Vanessa Hueren, Katharina Spengler, Vivek S. Bharadwaj, Zhanjun Guo, Anastasia E. Ledinina, Darja Deobald, Lorenz Adrian, Paul W. King, Kirstin Gutekunst   +14 more
wiley   +1 more source

A hierarchical nickel organic framework confers high conductivity over long distances in cable bacteria

Meysman FJR, Smets B, Hidalgo Martinez S, Claes N, Schroeder BC, Geelhoed JS, Liu Y, Choyikutty JA, Chennit T, Bodson T, Collauto A, Roessler MM, Karpov D, Bohic S, Aramini M, Hayama S, Wetherington M, Zwijnenburg MA, Pankratova G, Pintelon I, Timmermans J, Nuyts G, De Wael K, Bals S, Verbeeck J, Remaut H, Boschker HTS.   +26 more
europepmc   +1 more source

An Updated Ecology of Atlantic Salmon (Salmo salar) at Sea

Fisheries Oceanography, EarlyView.
ABSTRACT Atlantic salmon have had a key role in European and North American oceans and human societies. Salmon are exploited and observed in rivers and along coasts, but there has always been great interest in knowing where salmon are going when they are at sea.
Robert J. Lennox, Knut Wiik Vollset, Kjell Utne, Vidar Wennevik, Jessie Lilly, Eva B. Thorstad   +5 more
wiley   +1 more source

Effectiveness of Toothbrush Containing Solar Cells and Titanium Dioxide Rod on Plaque Reduction During Caregiver‐Performed Toothbrushing—Randomised Crossover Clinical Trial

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives This study was conducted to assess the effectiveness of a toothbrush containing solar cells and a titanium dioxide electrode (TiO2 toothbrush) compared with a normal toothbrush for removing plaque during caregiver‐performed oral hygiene care for elderly residents in nursing homes who require care. Methods A randomised, double‐blind,
Jumpei Murakami, Mai Niida
wiley   +1 more source