Three-step synthetic procedure to prepare dolutegravir, cabotegravir, and bictegravir
Green Chemistry Letters and Reviews, 2022 Dolutegravir, cabotegravir, and bictegravir are three integrase inhibitors, which were used for HIV-1 in the clinic. In this paper, a continuous three-step synthetic strategy was developed to prepare dolutegravir, cabotegravir, and bictegravir in a ...
Yuqi He, Changkuo Zhao, Xianheng Wang
exaly +4 more sources
Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans [PDF]
Pharmaceutics, 2023 Microarray patches (MAPs) are currently under investigation as a self-administered, pain-free alternative used to achieve long-acting (LA) drug delivery.
Hannah Kinvig +9 more
doaj +2 more sources
Breastmilk transfer of cabotegravir and infant safety outcomes in mothers on cabotegravir for HIV prevention in Lilongwe, Malawi: A protocol for an observational pharmacokinetic study, CABMILK Study [version 2; peer review: 2 approved, 1 approved with reservations] [PDF]
Wellcome Open ResearchBackground Long-acting injectable cabotegravir (CAB-LA) is highly effective for HIV pre-exposure prophylaxis (PrEP). However, lactating women have been underrepresented in pharmacokinetic and safety studies despite their elevated risk of HIV acquisition ...
Mina Hosseinipour +11 more
doaj +2 more sources
A Pharmacokinetic Dose-Optimization Study of Cabotegravir and Bictegravir in a Mouse Pregnancy Model [PDF]
Pharmaceutics, 2022 Animal pregnancy models can be useful tools to study HIV antiretroviral safety and toxicity and to perform mechanistic studies that are not easily performed in humans.
Haneesha Mohan +4 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Based on the structure of the anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells.
Xixi Hou
exaly +3 more sources
Seminal plasma concentrations of long-acting cabotegravir in men receiving HIV pre-exposure prophylaxis [PDF]
Antimicrobial Agents and ChemotherapyTo address the lack of data on male genital tract penetration of CAB-LA PrEP, seminal plasma was collected at days 3, 7, 28, 84, and 140 and analyzed by LC–MS/MS.
Davide Moschese +13 more
doaj +2 more sources
Effectiveness and Persistence of Long‐Acting Injectable Cabotegravir and Rilpivirine in Migrant Individuals Living With HIV in Spain: Substudy of the RELATIVITY Cohort [PDF]
Journal of the International AIDS SocietyIntroduction Migrants living with HIV often face high mobility, vulnerability and limited baseline information on HIV‐1 genotype or treatment history.
Jara Llenas‐García +62 more
doaj +2 more sources
Journal of Pharmaceutical Research, 2022 A simple, sensitive, specific, accurate, and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of cabotegravir and rilpivirine in injection dosage form, using a ...
A Suneetha +3 more
doaj +1 more source
Real-life efficacy and satisfaction of long-acting ART Cabotegravir-Rilpivirine in HIV-infected individuals [PDF]
Infectious Diseases and Tropical Medicine, 2023 OBJECTIVE: Switching from oral anti-retroviral therapy (ART) to intramuscular administration of Cabotegravir-Rilpivirine (CAB+RPV) has been observed to decrease the number of pills that patients need to take, enhance patient satisfaction, and promote ...
S. Spampinato +8 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2021 Background Using a Symmetry C18 (4.6 × 150 mm, 3.5) column, a high-performance liquid chromatographic method for quantification of Rilpivirine and Cabotegravir in active pharmaceutical ingredients was developed and validated.
Anuradha Vejendla +4 more
doaj +1 more source