Results 211 to 220 of about 539,116 (310)

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli   +12 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

open access: yesAdvanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim   +4 more
wiley   +1 more source

Electrolytic reduction of V3S4 in molten CaCl2

open access: yesElectrolytic reduction of V3S4 in molten CaCl2
Metallic vanadium was successfully produced starting from vanadium sulfide by applying electrolysis in molten CaCl2. Vanadium sulfide filled in a cathodic Ti basket and a graphite anode were immersed in the melt of CaCl2-CaS at 1173 K in Ar, and the electrolysis was conducted at a cell voltage of 3.0 V.
openaire  

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang   +7 more
wiley   +1 more source

Hierarchically Soft Porous MOF‐Polymer Monolith for Fast and Large‐Scale Moisture Buffering

open access: yesAdvanced Science, EarlyView.
A soft, hierarchical porous monolith that combines metal–organic frameworks (MOFs) with a thermoresponsive polymer matrix enables rapid, large‐scale moisture buffering. The synergistic interface facilitates high‐capacity water capture and low‐energy release for sustainable indoor dehumidification.
Guangxin Ma   +9 more
wiley   +1 more source

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

open access: yesAdvanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková   +5 more
wiley   +1 more source

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