Results 101 to 110 of about 3,058 (206)

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Mid‐Domain Effect and Wooded Habitat Shape Mediterranean Reptile Communities

Biological Diversity, EarlyView.
Analyzing a large number of reptiles observed across protected areas in Central Italy, we tested whether the mid‐domain effect explains hump‐shaped richness–elevation patterns. Species richness was best predicted by the combined influence of geometric constraints and woodland cover, revealing two contrasting species clusters and offering a robust ...
Daniele Dendi, Lauren De Nardi, Giovanni Amori, Luca Luiselli   +3 more
wiley   +1 more source

Past and Future of Sustainability Indicator Research in Agribusiness: A Bibliometric and Forecasting Analysis

Business Strategy and the Environment, EarlyView.
ABSTRACT This study offers a forward‐looking assessment of sustainability indicator research in agribusiness by integrating bibliometric mapping with ARIMA‐based forecasting. Analysing 403 Scopus‐indexed articles, bibliographic‐coupling analysis identifies three contemporary thematic domains: Techno‐Managerial Sustainability, Systemic and ...
Marcelo Kratz Mendes, Olga Cam, Aurora Carneiro Zen, Roger de Bem Jaeger, Daniela Callegaro‐de‐Menezes, Juliana Matos de Meira   +5 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

A [3]Rotaxane Containing {Ti7Ga} Rings Linking CuII: Synthesis, Structure, and Spectroscopic Studies

Chemistry – A European Journal, EarlyView.
Extended hybrid inorganic‐organic [2]‐ and [3]‐rotaxanes are reported based on heterometallic rings with threads that link CuII complexes; the crystal structures are reported, and the solution behavior is investigated by double electron electron resonance spectroscopy methods.
Selena J. Lockyer, Lubomir Loci, George F. S. Whitehead, Inigo J. Vitorica‐Yrezabal, Grigore A. Timco, Alice M. Bowen, Eric J. L. McInnes, Richard E. P. Winpenny   +7 more
wiley   +1 more source

Análisis y síntesis de la operación de circuitos secundarios de agua fría en climatización centralizada//Analysis and synthesis of the secondary circuits of cold water operation in centralized air conditioning systems

Ingeniería Mecánica, 2012
En el presente trabajo se desarrolla la metodología del Análisis y Síntesis de Sistemas de Ingeniería para la preparación y toma de decisiones durante la operación en la climatización centralizada a flujo variable.
Reineris Montero-Laurencio, Jesús Rafael Hechavarría Hernández, Arístides Alejandro Legrá-Lobaina, Aníbal Borroto-Nordelo, Rubier Santos-González   +4 more
doaj  

Isodesmic Supramolecular Assembly of Phenylethynylene Bis‐Urea Macrocycles

Chemistry – A European Journal, EarlyView.
A soluble phenylethynylene bis‐urea macrocycle assembles in polar media via an isodesmic hydrogen bonded mechanism. Spectroscopic and morphological studies reveal nanoscale aggregates with short chain length, while guest additives modulate enthalpy and polymerization, demonstrating tunable supramolecular assembly.
Fahidat A. Gbadamosi, Kazi Md Zubaer, Vaibhavi A. Samant, Jillian Eubanks, Sophya Garashchuk, Linda S. Shimizu   +5 more
wiley   +1 more source

Beyond goniometry: 3D digital twinning of droplets from a single image

Droplet, EarlyView.
We present a method to produce physics‐informed three‐dimensional digital twins of droplets from a single image for wettability analyses. We validate the method with goniometry and demonstrate its capabilities with advancing‐receding contact angle measurements, irregularly shaped droplets, and multi‐droplet systems, indicating strong potential for in ...
Isaac Berk, Emilie Luong, H. Jeremy Cho
wiley   +1 more source

Advancing mine pillar design: Evaluating traditional methods and integrating AI for enhanced stability of pillars in the Great Dyke, Zimbabwe

Deep Underground Science and Engineering, EarlyView.
B1 is bord width 1, B2 is bord width 2, L is the pillar length, W is the pillar width, red color and letter A represent the pillars, and white color and number 1 represent excavated areas. Pstress is the average pillar stress; σv is the vertical component of the virgin stress, MPa; and e is the areal extraction ratio. e = B o B o + B P ${\rm{e}}=\frac{{
Tawanda Zvarivadza, Hendrik Grobler, Peter Apata Olubambi, Moshood Onifade, Manoj Khandelwal   +4 more
wiley   +1 more source

Molecularly Engineered Dual‐Crosslinked Polymer Dielectrics for 200 °C Capacitive Energy Storage

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work establishes a molecular engineering strategy that constructs a robust dual‐crosslinked network in polymer nanocomposites, achieving a record‐high energy density of 5.17 J cm−3 with >90% efficiency at 200 °C. The multiscale‐validated design simultaneously enhances dielectric polarization and introduces deep electron traps, resulting in ...
Xue Li, Ling Weng, Lizhu Guan, Xiaoming Wang, Ze Li, Xiaorui Zhang, Ruiqun Pan, Yuhan Li, Zijian Wu, Yingtang Zhang   +9 more
wiley   +1 more source