Results 141 to 150 of about 346,942 (313)

Novo design de laminados oclusais ultrafinos CAD/CAM de resina composta e cerâmica para o tratamento de erosão severa [PDF]

open access: yes, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2010O objetivo deste estudo foi avaliar a influência de materiais para processamento CAD/CAM (cerâmica vs ...
Schlichting, Luís Henrique
core  

CAD '92. Neue Konzepte zur Realisierung anwendungsorientierter CAD-Systeme. GI-Fachtagung

open access: yes, 2022
Die Tagung CAD'92 war die erste Fachtagung der Gesellschaft für Informatik zum Thema "Rechnertinterstütztes Entwerfen und Konstruieren". Schwerpunkte der Tagung waren neue Konzepte zur Realisierung anwendungsorientierter CAD-Systeme.

core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Computer Technology and Woven Textile Design / or CAD

open access: yes, 2012
This chapter introduces some key issues regarding the use and role of CAD within the global textiles trading environment, such as: cost, expertise and skills training, impact on the supply chain and development of new products and new market areas.
Sinha, Pammi
core  

Seleção de sistemas CAD/CAE/CAM/ para moldes de injeção de plasticos atraves de testes de benchmark [PDF]

open access: yes, 1996
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoEste trabalho tem por objetivo global fornecer informações capazes de auxiliar as empresas da área de moldes no processo de seleção de sistemas CAD/CAE/CAM. Este auxílio é
Ribeiro Junior, Augusto
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

CAD of weak inherent coupled systems

open access: yes, 1994
The paper presents a general and simple CAD of weak inherent coupled systems. The developed algorithm uses the state-space description to avoid polynomial operations, and in turn the numerical stability is improved.
Mohamed, M., Ziedan, I., Moness, M.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Assessment of Six Polymorphic Variants as Genetic Risks for Coronary Artery Disease: A Case–Control Study

open access: yesMedical Journal of Babylon
Background: Coronary artery disease (CAD) is the leading cause of death worldwide. Certain genetic polymorphisms play an important role in this multifactorial disease, being linked with increased risk of early onset CAD.
Bassam Musa Sadik Al-Musawi   +1 more
doaj   +1 more source

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