Results 41 to 50 of about 346,942 (313)

An Approach of Rapid Tooling for Scalp Cooling Cap Design

open access: yes, 2019
This Innovate UK funded research studies the design, development and integration of a mass manufacturable scalp cooling cap using 3D anthropometric human head data. Scalp cooling is used to reduce hair loss for patients undergoing chemotherapy.
Burke, Patrick   +9 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Das CAD-Referenzmodell als Gestaltungsleitlinie für humanorientierte aufgabenbezogene CAD-Systeme

open access: yes, 2022
S.459-465By reason of the rather complicated handling of today's CAD systems well qualified and trained users are required. A sufficient support of the entire design work for product development is currently not yet possible.
Jansen, H.
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Federated Learning-Oriented Edge Computing Framework for the IIoT

open access: yesSensors
With the maturity of artificial intelligence (AI) technology, applications of AI in edge computing will greatly promote the development of industrial technology. However, the existing studies on the edge computing framework for the Industrial Internet of
Xianhui Liu   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tecnologia CAD/CAM [PDF]

open access: yes, 2013
TCC (graduação) – Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Odontologia.Nas últimas décadas, ocorreu um rápido avanço da ciência e um grande desenvolvimento tecnológico em diversas áreas.
Petter, Odara Íris
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Rechnerunterstützte Gestaltung dedizierter CAD-Werkzeuge

open access: yes, 2022
S.417-433The requirements on CAD tools vary with specific needs postulated by users and their tasks, by the type of product to be developed and by company oriented restrictions. The needs postulated can not be met by general purpose CAD systems.
Armbrust, P.   +2 more
core  

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