Results 51 to 60 of about 346,942 (313)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Digital assembly technology based on augmented reality and digital twins: a review
Virtual Reality & Intelligent Hardware, 2019 Product assembly simulation is considered as one of the key technologies in the process of complex product design and manufacturing. Virtual assembly realizes the assembly process design, verification, and optimization of complex products in the virtual ...
Chan Qiu +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Review of CAD-model Capabilities and Restrictions for Multidisciplinary use
, 2017 Product development is an iterative process, partially due to changes in both company internal and external product requirements, resulting in changes to the product under development.
Johansson, Joel, +9 more
core +1 more source
Risk Factors for Acute Kidney Injury After Hip Fracture Surgery in the Elderly Individuals
Geriatric Orthopaedic Surgery & Rehabilitation, 2012 Objective: We aimed to evaluate possible risk factors assocıated wıth acute kidney injury (AKI) after hip fracture surgery in the elderly individuals. Design: Level II diagnostic study, evidence obtained from prospective cohort study from 1 center with ...
Cagatay Ulucay +6 more
doaj +1 more source
Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD) [PDF]
Journal of Clinical and Diagnostic Research, 2015 Telomere attrition has been linked to accelerate vascular ageing and seems to predispose for vascular disease. Our aim was to study the telomere length dynamics over time and in subsets of leukocytes from 15 patients with peripheral arterial disease ...
Dirk De Beer +3 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Optimal Measurement of Visual Transmission Design Based on CAD and Data Mining [PDF]
This study aims to build a complete visual transmission design optimization measurement system by integrating CAD (Computer-aided design) and DM (Data mining) technologies.
Yusoff, Irwan Syah Md +3 more
core +1 more source
Visual InformaticsIntegrating modern artificial intelligence (AI) techniques, particularly generative AI, holds the promise of revolutionizing computer-aided design (CAD) tools and the engineering design process.
Qiang Zou +4 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source