Results 41 to 50 of about 12,242,462 (299)

Das CAD-Referenzmodell als Gestaltungsleitlinie für humanorientierte aufgabenbezogene CAD-Systeme

, 2022
S.459-465By reason of the rather complicated handling of today's CAD systems well qualified and trained users are required. A sufficient support of the entire design work for product development is currently not yet possible.
Jansen, H.
core   +1 more source

Circulating miR‐130 and its target PPAR‐γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus

Molecular Genetics & Genomic Medicine, 2019
Background Patients of coronary artery disease (CAD) with type 2 diabetes mellitus (DM2) show increased mortality risk than CAD patients without DM2, while few biomarkers can be used to discriminate them.
Yonggang Yuan, Wanzhong Peng, Yongxing Liu, Zesheng Xu   +3 more
doaj   +1 more source

Prognostic value of CAD-RADS classification by coronary CTA in patients with suspected CAD

BMC Cardiovascular Disorders, 2021
Background The study sought to compare Coronary Artery Disease Reporting and Data System (CAD-RADS) classification with traditional coronary artery disease (CAD) classifications and Duke Prognostic CAD Index for predicting the risk of all-cause mortality
Zengfa Huang, Shutong Zhang, Nan Jin, Yun Hu, Jianwei Xiao, Zuoqin Li, Yang Yang, Ruihong Sun, Zheng Wang, Xiang Li, Yuanliang Xie, Xiang Wang   +11 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Role of lipoprotein-associated phospholipase A2 (LP-PLA2) in the prediction and assessment of the severity of coronary artery disease in patients with type 2 diabetes mellitus [PDF]

Journal of Medical Biochemistry
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a specific biomarker associated with an increased risk of coronary artery disease (CAD) development.
Kostovska Irena, Cekovska Svetlana, Tosheska'Trajkovska Katerina, Labudovic Danica, Brezovska-Kavrakova Julijana, Topuzovska Sonja, Ampova Hristina, Emin Melda, Petrushevska-Stanojevska Elena, Nedeska-Minova Natasa, Kostovski Ognen, Boshev Marjan   +11 more
doaj   +1 more source

An updated analysis on the association of polymorphism and smoking exposure with the increased risk of coronary heart disease

Journal of International Medical Research, 2022
Objective To undertake a meta-analysis to investigate if there is an association between the glutathione S-transferase mu 1 ( GSTM1 ) gene polymorphism, coronary artery disease (CAD) susceptibility and smoking.
Min Liu, Ye Gu, Jian-Ning Ma, Ke-Na Bao, Li Ao, Xin Ni   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Frequency and Clinical Impact of Family History of Coronary Artery Disease in Patients with Vasospastic Angina

Journal of Cardiovascular Development and Disease, 2023
Background: Family history (FH) of coronary artery disease (CAD) [FH-CAD] is a well-known risk factor for atherosclerotic CAD. However, FH-CAD frequency in patients with vasospastic angina (VSA) remains unknown, and the clinical characteristics and ...
Hiroki Teragawa, Yuko Uchimura, Chikage Oshita, Yu Hashimoto, Shuichi Nomura   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source