Results 61 to 70 of about 12,771,392 (254)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Saudi Journal of Gastroenterology, 2016 Background/Aim: The risk of upper gastrointestinal bleeding (UGIB) increases in patients with coronary artery disease (CAD) due to the frequent use of antiplatelets. There is some data reporting on treatment outcomes in CAD patients presenting with UGIB.
Kessarin Thanapirom +15 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Oman Medical Journal, 2018 Objectives: ATP-binding cassette transporter A1 (ABCA1) plays a pivotal role in reverse cholesterol transport from peripheral tissues back to the liver. Abnormalities in ABCA1 function may lead to dyslipidemia and coronary artery disease (CAD).
Khalil Mahmoodi +3 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Point cloud dataset creation for machine learning on CAD models [PDF]
, 2020 Recently, the application of machine learning on Computer-Aided Design (CAD) models has emerged. However, there is a lack of robust methods for the conversion of boundary representation (B-Rep) CAD models from engineering software to appropriate input ...
Hua, Yang; id_orcid +10 more
core +1 more source
OPTIMISATION OF A U-BEND USING A CAD-BASED ADJOINT METHOD WITH DIFFERENTIATED CAD KERNEL [PDF]
Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016), 2016 In order to optimise the shape of a three-dimensional CAD-based model using the computationally efficient adjoint methods, the calculation of shape sensitivities, the derivatives of the surface position with respect to the design parameters, is required.
Auriemma, S. +6 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2022 S.34-49In der Konstruktion, der Domaene von CAD-Systemen, kommen vermehrt auch Werkzeuge zum computerunterstuetzten kooperativen Arbeiten (CSCW-Tools) und Virtual Reality (VR) Systeme zum Einsatz.
Rix, J., Stork, A., Jasnoch, U.
core
Computer aids and human second reading as interventions in screening mammography: two systematic reviews to compare effects on cancer detection and recall rate [PDF]
, 2008 Background: There are two competing methods for improving the accuracy of a radiologist interpreting screening mammograms: computer aids (CAD) or independent second reading. Methods: Bibliographic databases were searched for clinical trials.
Paul Taylor +3 more
core +1 more source