Results 81 to 90 of about 12,771,392 (254)

Changes and significance of high-density lipoprotein A-I, A-II, and serum amyloid levels in patients with chronic obstructive pulmonary disease complicated by coronary heart disease

Clinical and Experimental Hypertension
Objective To investigate the significance of blood lipids and pro-inflammatory in chronic obstructive pulmonary disease (COPD) patients in stable and acute exacerbations (AECOPD) with or without coronary heart disease (CAD).Methods One hundred and sixty ...
Yao Tian, Hongru Liu, Yaoyong Wang
doaj   +1 more source

NE-nu-SVC: A New Nested Ensemble Clinical Decision Support System for Effective Diagnosis of Coronary Artery Disease

IEEE Access, 2019
Coronary artery disease (CAD) is one of the main causes of cardiac death around the world. Due to its significant impact on the society, early and accurate detection of CAD is essential.
Moloud Abdar, U. Rajendra Acharya, Nizal Sarrafzadegan, Vladimir Makarenkov   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Rechnerunterstützte Gestaltung dedizierter CAD-Werkzeuge

, 2022
S.417-433The requirements on CAD tools vary with specific needs postulated by users and their tasks, by the type of product to be developed and by company oriented restrictions. The needs postulated can not be met by general purpose CAD systems.
Armbrust, P., Bienert, M., Vosgerau, F.H.   +2 more
core   +1 more source

Increased risk of thrombotic events in cold agglutinin disease: A 10‐year retrospective analysis

Research and Practice in Thrombosis and Haemostasis, 2020
Background Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia mediated by IgM autoantibodies that trigger hemolysis via classical complement pathway. Increased incidence of thrombotic events (TEs) has been reported in patients with other
Catherine M. Broome, Julia M. Cunningham, Megan Mullins, Xiaohui Jiang, Lauren C. Bylsma, Jon P. Fryzek, Adam Rosenthal   +6 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Computergraphik für CAD - ein F&E-Beitrag aus Darmstadt

, 2022
S.9-45In diesem Heft wird über einige der F und E Arbeiten aus Darmstadt berichtet, um einen Querschnitt zu dem Thema "CAD und Computergraphik" zu geben.
Rix, J., Encarnação, José L.
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease

Biomedical Engineering and Computational Biology
Introduction: Coronary artery disease (CAD) is a major global cause of morbidity and mortality. Therefore, advances in early identification and individualized treatment plans are crucial.
Fathima Lamya, Muhammad Arif, Mahbuba Rahman, Abdul Rehman Zar Gul, Tanvir Alam   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source