Results 81 to 90 of about 12,242,462 (299)
Clinical and Experimental HypertensionObjective To investigate the significance of blood lipids and pro-inflammatory in chronic obstructive pulmonary disease (COPD) patients in stable and acute exacerbations (AECOPD) with or without coronary heart disease (CAD).Methods One hundred and sixty ...
Yao Tian, Hongru Liu, Yaoyong Wang
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease
Biomedical Engineering and Computational BiologyIntroduction: Coronary artery disease (CAD) is a major global cause of morbidity and mortality. Therefore, advances in early identification and individualized treatment plans are crucial.
Fathima Lamya +4 more
doaj +1 more source
Curvature Matched Machining Methods Versus Commercial CAD Methods [PDF]
, 1999 This paper examines the benefits that are realized when five-axis curvature matched machining methods (CM) are used to machine typical automobile stamping die geometry. Three-axis ball end mill methods are used as the baseline of comparison for CM. Two doubly curved sample surfaces which represent an automotive stamping die are machined using: 1) three-
K. A. White, J. K. Hill, C. G. Jensen
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2013 Szakdolgozatomba az általam három legjobban ismert CAD rendszer bemutatását céloztam meg. Ezek az ArchiCAD, a FactoryCAD és a SolidWorks. A CAD fogalma, a CAD rendszerek kialakulásának történelme mellett álltalánosan a CAD rendszerek előnyeiről is szót ...
Böszörményi, Csaba
core
Retracted: Supervised Computer-Aided Diagnosis (CAD) Methods for Classifying Alzheimer's Disease-Based Neurodegenerative Disorders. [PDF]
Comput Math Methods Med, 2023 Methods In Medicine CAM.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source