Results 101 to 110 of about 12,242,462 (299)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Konfigurierbare CAD-Applikationen auf der Basis eines flexiblen Benutzungsoberflaechen-Systems

, 2022
S.317-332Dieser Artikel geht auf die speziellen Anforderungen der Anpassung und Konfigurierung von CAD-Systemumgebungen im Hinblick auf eine staerkere Aufgabenorientierung der CAD-Prozesse und auf eine konsistent und flexibel gestaltete CAD ...
Koch, M., Haßinger, S.
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A hierarchical multilevel modeling framework for the creation of high-quality solid models in parametric feature-based CAD systems [PDF]

[EN] Building on the premise that quality is a complex and multifaceted concept, we advocate for the structuring of the concept of quality in engineering design parametric CAD modeling by using three hierarchical levels. The goal is to successfully parse
Company, Pedro, Camba, Jorge D., Justel, Daniel, Company, P., Justel, D., Camba, J.D., Aranburu, A., Aranburu, Aritz, Contero, Manuel   +8 more
core   +2 more sources

Wandel der Entwicklungsziele für CAD-Systeme

, 2022
S.1-18Durch die gewonnenen Erfahrungen bei Anwendung der CAD-Technologie sind die Anforderungen an zukünftige Systeme klarer geworden. Es geht nicht mehr nur um die Realisierung von Einzelfunktionen. So wie andere Bausteine der rechnerintegrierten Fabrik
Krause, F.-L.
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Review of CAD-model Capabilities and Restrictions for Multidisciplinary use

, 2017
Product development is an iterative process, partially due to changes in both company internal and external product requirements, resulting in changes to the product under development.
Johansson, Joel,, Fredrik Elgh, Johansson, Joel, Joel Johansson, Heikkinen, Tim,, Frederik Elgh, Elgh, Fredrik,, Heikkinen, Tim, Tim Heikkinen, Elgh, Fredrik   +9 more
core   +1 more source