Results 71 to 80 of about 12,771,392 (254)

Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study

American Journal of Preventive Cardiology
Objective: Cancer survivors have an increased risk of developing coronary artery disease (CAD). We introduce CAD polygenic risk scores (PRS) and examine associations with cancer status on CAD outcomes.
Yidan Wang, Shan Zhong, Na Sun, Yunfei Wu, Jun Lyu, Minghui Piao, Wenbo Qu, Xueyu Wang, Wenjun Ni, Xia Gu, Tianshu Han, Jinwei Tian   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CAD und Animation im Produktentwicklungsprozeß

, 2022
S.84-91Die Zielsetzung dieses Berichtes ist es, einen Diskussionsbeitrag zur Kopplung von CAD mit Animationssystemen zu geben. Der Beitrag den Produktentwicklungszyklus, der durch die Mehrfachnutzung eines computerinternen Produktmodells effizienter ...
Koch, M., Loseries, F.
core  

The validity and applicability of CAD-RADS in the management of patients with coronary artery disease

Insights into Imaging, 2019
Background The coronary artery disease reporting and data system (CAD-RADS) is designed for a uniform standardization of coronary computed tomography angiography (CCTA) reporting and further management recommendations of coronary artery disease (CAD ...
Mohammad Abd Alkhalik Basha, Sameh Abdelaziz Aly, Ahmad Abdel Azim Ismail, Hanan A. Bahaaeldin, Samar Mohamad Shehata   +4 more
doaj   +1 more source

Comparison of coronary artery disease guidelines with extracted knowledge from data mining [PDF]

Journal of Cardiovascular and Thoracic Research, 2017
Introduction: Coronary artery disease (CAD) is one of the major causes of disability and death in the world. Accordingly utilizing from a national and update guideline in heart-related disease are essential.
Peyman Rezaei-Hachesu, Azadeh Oliyaee, Naser Safaie, Reza Ferdousi   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Review of CAD-model Capabilities and Restrictions for Multidisciplinary use

, 2017
Product development is an iterative process, partially due to changes in both company internal and external product requirements, resulting in changes to the product under development.
Johansson, Joel,, Fredrik Elgh, Johansson, Joel, Joel Johansson, Heikkinen, Tim,, Frederik Elgh, Elgh, Fredrik,, Heikkinen, Tim, Tim Heikkinen, Elgh, Fredrik   +9 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Engineering design using game-enhanced CAD: The potential to augment the user experience with game elements [PDF]

, 2012
Since the coining of the term ‘serious games’ by Clark Abt, practitioners in fields such as education, the military, medical science, as well as researchers from other disciplines, have investigated with interest game mechanics and the dynamics of games ...
Lim, Theodore; id_orcid, Ritchie, James Millar, Liu, Ying, Sung, Raymond, Kosmadoudi, Zoe, Louchart, Sandy   +5 more
core   +1 more source