Results 81 to 90 of about 9,876 (239)

Driving research on successful aging and neuroprotection in Latin America: Insights from the inaugural symposium on brain resilience and healthy longevity

open access: yesAlzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Global life expectancy has steadily increased in recent decades, resulting in a significant rise in the number of individuals aged 80 years and older. This trend is also evident in Latin America, where life expectancy is improving, though at varying rates across countries and regions.
Yakeel T. Quiroz   +18 more
wiley   +1 more source

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [PDF]

open access: yesVojnosanitetski Pregled, 2011
Introduction. Fast and precise diagnostics of the disease from the large group of adult leukoencephalopathy is difficult but responsible job, because the outcome of the disease is very often determined by its name.
Krsmanović Željko   +7 more
doaj   +1 more source

The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center

open access: yesAlzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Alzheimer's disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular neuropathologies occur together. Previous studies have been limited by a large majority of participants with severe dementia or advanced stages of pathologies, which limits the detectability of cognitive effects from vascular neuropathologies.
Cellas A. Hayes   +9 more
wiley   +1 more source

Peripheral neuropathy in a case with CADASIL: a case report

open access: yesBMC Neurology, 2018
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by central nervous system dysfunctions. It is unclear whether CADASIL is involved in peripheral neuropathy.
Yusuke Sakiyama   +10 more
doaj   +1 more source

Virchow-Robin spaces : an anatomic variant or a pathologic sign? [PDF]

open access: yes, 2009
Virchow-Robin spaces surround blood vessels. Their walls are formed by prolongations of the pia mater and they have no communication with the subarachnoid space. VRS are often seen as well-delineated foci of cerebrospinal fluid signal on MR images.

core  

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

open access: yesThe Journal of Headache and Pain, 2019
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment.
Jingjing Su   +10 more
doaj   +1 more source

The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1–6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7–34 pathogenic variant [PDF]

open access: yes, 2019
Purpose: CADASIL is a small-vessel disease caused by a cysteine-altering pathogenic variant in one of the 34 epidermal growth factor-like repeat (EGFr) domains of the NOTCH3 protein.
A. Federico   +10 more
core   +1 more source

Stroke and associated comorbidities in Southeast Asian countries

open access: yesNeuroprotection, Volume 3, Issue 1, Page 29-47, March 2025.
Different diseases can act as comorbid factors of stroke. Among them, hyperglycemia, hypertension, hyperlipidemia, atrial fibrillation, cancer, and chronic kidney disease act as major comorbidities. Whereas migraine, Fabry disease, Moyamoya disease, sickle cell disease, cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Aishika Datta   +9 more
wiley   +1 more source

Novel mutations in HTRA1‐related cerebral small vessel disease and comparison with CADASIL

open access: yesAnnals of Clinical and Translational Neurology, 2022
Objective There is evidence showing both heterozygous HTRA1 and homozygous HTRA1 mutations as causal for familial cerebral small vessel disease (CSVD).
Chen Zhang   +8 more
doaj   +1 more source

Free Water as a Marker of Early Small Vessel Disease in Healthy Aging

open access: yesEuropean Journal of Neurology, Volume 32, Issue 3, March 2025.
ABSTRACT Background Brain aging is associated with cerebrovascular changes and related microstructural pathology. In this context, research indicates that small vessel disease (SVD) is characterized by increases in extracellular free water (FW). Methods We examined 94 individuals with early signs of small vessel disease (eSVD; Mage = 69.47 years, SDage 
Manuel Leitner   +6 more
wiley   +1 more source

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