Results 61 to 70 of about 8,915 (192)

Clinical pregenetic screening for stroke monogenic diseases: Results from lombardia GENS registry [PDF]

, 2016
BACKGROUND AND PURPOSE: Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS
Agostoni, E, Arbustini, E, Arnaboldi, M, Baratta, S, Baron, P, Bassi, Mt, Beretta, S, Bersano, A, Boncoraglio, Gb, Bono, G, Bordo, Bm, Braga, M, Calloni, Mv, Candelise, L, Capitani, E, Carrera, P, Cavallini, A, Cereda, C, Checcarelli, N, Colombo, A, Comi, G, Comi, Gp, Corato, M, Corti, S, De Lodovici, Ml, Ferrarese, C, Ferrari, M, Fusi, L, Gellera, C, Grampa, G, Grasso, M, Grieco, G, Grond-Ginsbach, C, Guidotti, M, Incorvaia, B, Lanfranconi, S, Marcheselli, S, Markus, Hs, Mazucchelli, F, Merlini, G, Micieli, G, Molini, G, Mosca, L, Motto, C, Obici, L, Padovani, A, Parati, Ea, Penco, S, Perrone, P, Pezzini, A, Quaglini, S, Ronchi, D, Sasanelli, F, Sessa, M, Tadeo, Cs, Tancredi, L, Taroni, F, Trobia, N, Uccellini, D, Verrengia, Ep, Vitali, P, Zarcone, D   +61 more
core   +1 more source

Topography and cognitive impact of brain iron deposition in cerebral amyloid angiopathy: Evidence from 7T quantitative susceptibility mapping

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While brain iron accumulation has been linked to cognitive impairment in aging and small vessel diseases, its spatial pattern and clinical significance in cerebral amyloid angiopathy (CAA) remain poorly defined. METHODS Quantitative susceptibility mapping (QSM) was used to assess region‐specific iron deposition across cortical ...
Yijun Lin, Yang Du, Guangshuo Li, Bin Gao, Mengyao Li, Liheng Bian, Tao Wu, Xingquan Zhao   +7 more
wiley   +1 more source

An Integrated QSM‐Radiomics Nomogram With Clinical and Imaging Markers for Stratifying Cognitive Impairment in Hypertension

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
This study developed an integrated nomogram combining QSM‐based radiomics, brain iron deposition, white matter hyperintensity, and clinical markers. This model demonstrated superior performance in stratifying hypertensive cognitive impairment compared to traditional single‐parameter models.
Yu Su, Tingting Liu, Chengjun Dong, Limin Ge, Tianxiang Li, Zhiqing Zhang, Yihan Zhang, Chungao Li, Jie Zhao, Chuansheng Zheng, E. Mark Haacke, Wenjun Wu, Lixia Wang   +12 more
wiley   +1 more source

Global Research Trends and Hotspots in Cerebral Small Vessel Disease‐Related Cognitive Impairment: A Bibliometric Analysis (2001–2024)

Brain and Behavior, Volume 16, Issue 1, January 2026.
This bibliometric study systematically analyzed 1074 publications in the field of CSVD‐CI from 2001 to 2024. The research reveals three evolutionary phases and identifies four core research clusters: pathophysiological mechanisms, neuroimaging biomarkers, clinical assessment, and therapeutic interventions.
Kuihua Wang, Xiaohui Ji, Hui Li, Xiaoyang Wang, Xiaoyue Jin, YanJun Lin, Qiao Wang, Haizhen Xu, Jianxin Ye, Xiaoping Cui, Yonghui Liang   +10 more
wiley   +1 more source

Is migraine a common manifestation of CADASIL? Arguments Pros

The Journal of Headache and Pain
Background Migraine with aura (MA) is a hallmark feature of CADASIL, a hereditary small-vessel disease caused by NOTCH3 mutations. While MA is prevalent in CADASIL, its underlying mechanisms remain unclear, and the links observed can be questioned or ...
Hugues Chabriat
doaj   +1 more source

Advanced Imaging Applications in Tumefactive Demyelination – Literature Review With an Illustrative Case Report

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and Purpose Solitary tumefactive demyelinating lesions (TDLs) represent an uncommon but clinically significant manifestation of central nervous system demyelination and pose a major diagnostic challenge due to their radiologic resemblance to high‐grade gliomas, primary central nervous system lymphoma, and other mass‐like lesions ...
Joga Chaganti, Michelle Dellalana, Kiran Talekar, Jay Thakkar, Scott H. Faro   +4 more
wiley   +1 more source

Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis

Neurobiology of Disease, 2015
Could impaired adult hippocampal neurogenesis be a relevant mechanism underlying CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)? Memory symptoms in CADASIL, the most common hereditary form of vascular
Fanny Ehret, Steffen Vogler, Sherin Pojar, David A. Elliott, Frank Bradke, Barbara Steiner, Gerd Kempermann   +6 more
doaj   +1 more source

Adaptive metabolic changes in CADASIL white matter [PDF]

, 2018
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an important genetic cause of stroke, but pathogenic mechanisms and functional alterations remain poorly characterized.
Akhvlediani, Tamar, Boesiger, Peter, Henning, Anke, Jung, Hans, Sándor, Peter   +4 more
core  

Grey matter volume alterations in CADASIL: a voxel-based morphometry study [PDF]

, 2012
CADASIL is a hereditary disease characterized by cerebral subcortical microangiopathy leading to early onset cerebral strokes and progressive severe cognitive impairment.
ROSSI ESPAGNET, MARIA CAMILLA, ROMANO, Andrea, CARDUCCI, Filippo, ORZI, Francesco, BOZZAO, ALESSANDRO, Mcr Espagnet, Maria Camilla Rossi Espagnet, Luigi Fausto Calabria, Martina Fiorillo   +8 more
core   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source