Results 1 to 10 of about 2,850,125 (303)

The Role of Notch Receptors in Transcriptional Regulation [PDF]

Journal of Cellular Physiology, 2015
Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and homeostasis of adult tissues.
Hongfang Wang, C. Zang, X. Liu, J. Aster
semanticscholar   +3 more sources

A toolkit for studying cell surface shedding of diverse transmembrane receptors

eLife, 2019
Proteolysis of transmembrane receptors is a critical cellular communication mechanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed receptors is hindered by difficulties controlling stimuli and unknown fates ...
Amanda N Hayward, Eric J Aird, Wendy R Gordon   +2 more
doaj   +1 more source

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

Molecular Cancer, 2016
Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year survival rate of GC is rather low.
Tingting Huang, Yuhang Zhou, A. S. Cheng, Jun Yu, K. To, W. Kang   +5 more
semanticscholar   +1 more source

A Review on Notch Signaling and Colorectal Cancer

Cells, 2020
Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway.
A. Tyagi, Arun K. Sharma, Chendil Damodaran   +2 more
semanticscholar   +1 more source

NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells

Hematology Reports, 2018
NOTCH signaling diversely regulates the growth of acute myeloid leukemia (AML) cells. It is known that glycosylation of NOTCH receptors modulates NOTCH activation. However, little is known about glycosylation of NOTCH in AML cells.
Shichun Wang, Mai Itoh, Erika Shiratori, Mika Ohtaka, Shuji Tohda   +4 more
doaj   +1 more source

Identification and quantification of notch receptors in human cutaneous melanoma using molecular biology techniques: literature review

Surgical and Experimental Pathology, 2020
Background The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer.
Lorena Dal Collina Sangiuliano, Renato Santos de Oliveira Filho, Daniel Arcuschin de Oliveira, Heitor Carvalho Gomes, Lydia Masako Ferreira   +4 more
doaj   +1 more source

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a γ-Secretase Inhibitor

Clinical Cancer Research, 2015
Purpose: To identify and characterize novel, activating mutations in Notch receptors in breast cancer and to determine response to the gamma secretase inhibitor (GSI) PF-03084014.
Kai Wang, Qin Zhang, Danan Li, K. Ching, Cathy C Zhang, Xianxian Zheng, M. Ozeck, S. Shi, Xiaorong Li, Hui Wang, P. Rejto, J. Christensen, P. Olson   +12 more
semanticscholar   +1 more source

Differential effects of targeting Notch receptors in a mouse model of liver cancer

Hepatology, 2015
Primary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of liver architecture, is also a potential driver of primary liver cancer ...
E. Huntzicker, K. Hötzel, L. Choy, L. Che, J. Ross, Grégoire Pau, Neeraj Sharma, C. Siebel, Xin Chen, D. French   +9 more
semanticscholar   +1 more source

Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

Nature Communications, 2021
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell ...
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti   +12 more
doaj   +1 more source

No evidence for a functional role of bi-directional Notch signaling during angiogenesis. [PDF]

PLoS ONE, 2012
The Delta-Notch pathway is a signal exchanger between adjacent cells to regulate numerous differentiation steps during embryonic development. Blood vessel formation by sprouting angiogenesis requires high expression of the Notch ligand DLL4 in the ...
Sven S Liebler, Anja Feldner, M Gordian Adam, Thomas Korff, Hellmut G Augustin, Andreas Fischer   +5 more
doaj   +1 more source