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Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five
Laura Gragnani +3 more
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The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
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A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
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In vivo analysis of the Notch receptor S1 cleavage.
PLoS ONE, 2009 A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake +4 more
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Frontiers in Genetics, 2023 Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng +6 more
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Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions
Biomolecules, 2021 The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development ...
Wataru Saiki +3 more
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Significant Roles of Notch O-Glycosylation in Cancer
Molecules, 2022 Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang +2 more
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Cell Reports, 2023 Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian +5 more
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Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
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Infectious Microbes & Diseases, 2021 . Pattern-recognition receptors, such as toll-like receptors (TLRs), detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.
Yuna Zhao +7 more
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