Results 1 to 10 of about 611,342 (249)
Frontiers in Genetics, 2023 Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng +6 more
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Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions
Biomolecules, 2021 The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development ...
Wataru Saiki +3 more
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Significant Roles of Notch O-Glycosylation in Cancer
Molecules, 2022 Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang +2 more
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Cell Reports, 2023 Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian +5 more
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Infectious Microbes & Diseases, 2021 . Pattern-recognition receptors, such as toll-like receptors (TLRs), detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.
Yuna Zhao +7 more
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NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
Cells, 2020 The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and ...
María-Milagros Rodríguez-Cano +7 more
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Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
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Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
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Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis
Frontiers in Immunology, 2023 Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
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Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice [PDF]
Open Biology, 2016 Postnatal skeletal muscle growth results from the activation of satellite cells and/or an increase in protein synthesis. The Notch signalling pathway maintains satellite cells in a quiescent state, and once activated, sustains their proliferation and ...
Bilal Al Jaam +8 more
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