Results 31 to 40 of about 611,342 (249)

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]

, 2010
Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Mazur Pawel K., Radtke, Freddy, Freddy Radtke, Roland M Schmid, Schmid, Roland M., Nakhai Hassan, Grüner, Barbara M., Pawel K Mazur, Schmid Roland M., Barbara M. Grüner, Bence Sipos, Nakhai, Hassan, Jens T Siveke, Strobl Lothar J., Siveke, J.T., Mazur, P.K., Radtke Freddy, Sipos, Bence, Radtke, F., Barbara M Grüner, Zimber-Strobl Ursula, Nakhai, H., Jens T. Siveke, Sipos, B., Grüner, B.M., Schmid, R.M., Strobl, Lothar J., Grüner Barbara M., Strobl, L.J., Lothar J Strobl, Lothar J. Strobl, Zimber-Strobl, Ursula, Hassan Nakhai, Pawel K. Mazur, Roland M. Schmid, Mazur, Pawel K., Ursula Zimber-Strobl, Sipos Bence, Siveke Jens T., Zimber-Strobl, U., Siveke, Jens T.   +40 more
core   +3 more sources

No evidence for a functional role of bi-directional Notch signaling during angiogenesis. [PDF]

PLoS ONE, 2012
The Delta-Notch pathway is a signal exchanger between adjacent cells to regulate numerous differentiation steps during embryonic development. Blood vessel formation by sprouting angiogenesis requires high expression of the Notch ligand DLL4 in the ...
Sven S Liebler, Anja Feldner, M Gordian Adam, Thomas Korff, Hellmut G Augustin, Andreas Fischer   +5 more
doaj   +1 more source

Notch Ligand Binding Assay Using Flow Cytometry

Bio-Protocol, 2017
Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
doaj   +1 more source

Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer

BMC Cancer, 2022
Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast ...
Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah   +13 more
doaj   +1 more source

The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]

, 2011
Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core   +1 more source

The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]

, 2004
The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
core   +2 more sources

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. [PDF]

PLoS ONE, 2011
The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1 ...
Jon C Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C Blacklow, Warren S Pear   +9 more
doaj   +1 more source

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

eLife, 2017
The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4, but
Shogo Sawaguchi, Shweta Varshney, Mitsutaka Ogawa, Yuta Sakaidani, Hirokazu Yagi, Kyosuke Takeshita, Toyoaki Murohara, Koichi Kato, Subha Sundaram, Pamela Stanley, Tetsuya Okajima   +10 more
doaj   +1 more source

Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]

, 2006
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
core   +2 more sources

Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver

BMC Research Notes, 2023
The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which is recognized
Masaharu Yoshihara, Takahiro Nakayama, Satoru Takahashi   +2 more
doaj   +1 more source