Results 31 to 40 of about 2,850,125 (303)
Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
doaj +1 more source
Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
doaj +1 more source
Relevance of Notch Signaling for Bone Metabolism and Regeneration
International Journal of Molecular Sciences, 2021 Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation and apoptosis.
T. Ballhause +7 more
semanticscholar +1 more source
Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis
Frontiers in Immunology, 2023 Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
doaj +1 more source
Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice [PDF]
Open Biology, 2016 Postnatal skeletal muscle growth results from the activation of satellite cells and/or an increase in protein synthesis. The Notch signalling pathway maintains satellite cells in a quiescent state, and once activated, sustains their proliferation and ...
Bilal Al Jaam +8 more
doaj +1 more source
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
Cell, 2016 The Notch protein is one of the most mechanistically direct transmembrane receptors – the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular ligand induces ...
Leonardo Morsut +6 more
semanticscholar +1 more source
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
Cell, 2016 Redirecting T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic capabilities. But the effectiveness of therapeutic T cells is constrained by the endogenous T cell response: certain facets of natural response ...
Kole T. Roybal +8 more
semanticscholar +1 more source
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies
Frontiers in Immunology, 2018 The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis.
Michelle A. Kelliher +1 more
doaj +1 more source
The NOTCH receptor and its ligands
Trends in Cell Biology, 1997 An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming +2 more
openaire +2 more sources
Diversity in Notch ligand-receptor signaling interactions
eLife, 2023 Abstract The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulated by ...
Rachael Kuintzle +2 more
openaire +4 more sources