Results 11 to 20 of about 2,850,125 (303)
Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five
Laura Gragnani +3 more
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Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
Cell, 2018 Summary Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. We find three paralogs of
Meghan Mooring +2 more
exaly +2 more sources
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Frontiers in Immunology, 2021 The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos +8 more
doaj +2 more sources
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
doaj +5 more sources
The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +4 more sources
The Notch Pathway in Breast Cancer Progression
The Scientific World Journal, 2018 Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of
Emmanuel N. Kontomanolis +6 more
doaj +2 more sources
In vivo analysis of the Notch receptor S1 cleavage.
PLoS ONE, 2009 A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake +4 more
doaj +5 more sources
Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. [PDF]
Experimental Hematology, 2000 Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
Nita Singh +4 more
semanticscholar +3 more sources
Nature Communications, 2017 ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited ...
Qiyu Wang, Quan Lu
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Literature review of Notch melanoma receptors
Surgical and Experimental Pathology, 2019 Despite the immunotherapeutics and target therapy agents, the survival of patients with advanced melanoma is still low. Notch signaling is able to regulate many aspects of melanomagenesis.
Renato Santos de Oliveira Filho +7 more
doaj +2 more sources