Results 11 to 20 of about 611,342 (249)
Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five
Laura Gragnani +3 more
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The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +4 more sources
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
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Expression of Notch Receptors and Ligands in the Adult Gut [PDF]
Journal of Histochemistry & Cytochemistry, 2004 The Notch signaling pathway has become recognized as a vitally important pathway in regulating proliferative/differentiative decisions and cell fate. To explore the involvement of the Notch pathway in adult gut, we investigated the expression of Notch receptors and their ligands by Northern blotting and in situ hybridization.
Sander, G., Powell, B.
openaire +4 more sources
In vivo analysis of the Notch receptor S1 cleavage.
PLoS ONE, 2009 A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake +4 more
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Non-small-cell lung carcinoma: role of the Notch signaling pathway
Lung Cancer: Targets and Therapy, 2015 Levi Barse, Maurizio Bocchetta Department of Pathology, Oncology Institute, Loyola University Chicago, Maywood, IL, USA Abstract: Notch signaling plays a pivotal role during embryogenesis.
Barse L, Bocchetta M
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The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]
, 2013 Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
core +6 more sources
Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
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Notch receptor and Notch ligand expression in developing avian cartilage [PDF]
Journal of Anatomy, 2009 AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams +4 more
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Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis [PDF]
Experimental Hematology, 2000 Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
N, Singh +3 more
openaire +2 more sources