Results 41 to 50 of about 2,850,125 (303)
Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
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Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. [PDF]
PLoS ONE, 2011 The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1 ...
Jon C Aster +9 more
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The Varied Roles of Notch in Cancer
Annual Review of Pathology, 2016 Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context.
J. Aster, W. Pear, S. Blacklow
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Cells, 2020 Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described.
G. Moore +3 more
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BMC Cancer, 2022 Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast ...
Hassan Yousefi +13 more
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eLife, 2017 The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4, but
Shogo Sawaguchi +10 more
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Precision medicine for human cancers with Notch signaling dysregulation (Review)
International Journal of Molecular Medicine, 2019 NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2.
Masuko Katoh, M. Katoh
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Notch Signaling in Breast Cancer: A Role in Drug Resistance
Cells, 2020 Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2.
M. BeLow, C. Osipo
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Regulation of myeloid and lymphoid cell development by O-glycans on Notch
Frontiers in Molecular Biosciences, 2022 Notch signaling via NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand DLL1 is required for the development of marginal zone (MZ) B cells in spleen.
Pamela Stanley, Ankit Tanwar
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Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
PLOS ONE, 2016 Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling ...
Maxwell Greene +5 more
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