Results 61 to 70 of about 2,850,125 (303)
Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation
Communications Biology, 2020 Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific ...
Zijie Yang +4 more
semanticscholar +1 more source
Expression of Notch Receptors and Ligands in the Adult Gut [PDF]
Journal of Histochemistry & Cytochemistry, 2004 The Notch signaling pathway has become recognized as a vitally important pathway in regulating proliferative/differentiative decisions and cell fate. To explore the involvement of the Notch pathway in adult gut, we investigated the expression of Notch receptors and their ligands by Northern blotting and in situ hybridization.
Sander, G., Powell, B.
openaire +3 more sources
Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
Molecular Cancer, 2009 Background Recent studies have implicated aberrant Notch signaling in breast cancers. Yet, relatively little is known about the pattern of expression of various components of the Notch pathway, or its mechanism of action. To better understand the role of
Dey Devaveena +4 more
doaj +1 more source
Development, 2012 In the developing lung, it is thought that the terminal buds of elongating airways contain a population of multipotent epithelial progenitors. As the bronchial tree extends, descendants of these cells give rise to lineage-restricted progenitors in the ...
M. Morimoto +3 more
semanticscholar +1 more source
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]
Cell Research, 2014 Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Sjöqvist, M. +12 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cis-activation in the Notch signaling pathway
eLife, 2019 The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling.
Nagarajan Nandagopal +2 more
doaj +1 more source
Mammalian NOTCH Receptor Activation and Signaling Protocols
, 2022 The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both developmental and adult stages in most animals. The NOTCH signaling pathway appears to be very simple but the existence of several receptors and ligands, their posttranslational modifications, their ...
Nueda Sanz, María Luisa +1 more
openaire +3 more sources
Nuclear βII-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling [PDF]
Cancer Research, 2004 Abstract The Notch signal pathway plays important roles in proliferation, apoptosis, and differentiation. Abnormalities in Notch signaling are linked to many human diseases. After ligand binding, Notch signaling is activated through the cleavage of Notch receptors to release and translocate the Notch intracellular domain into the nucleus.
Tien-Shun, Yeh +6 more
openaire +2 more sources
Notch receptors in GtoPdb v.2021.2
IUPHAR/BPS Guide to Pharmacology CITE, 2021 Aberrant Notch signalling is implicated in a number of human cancers [18, 26, 13, 21], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [7, 16].
Christopher Sobey, Thiruma V. Arumugam
openaire +2 more sources