Results 71 to 80 of about 611,342 (249)

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]

Cell Research, 2014
Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Sjöqvist, M., Antfolk, D., Ferraris, S., Rraklli, V., Haga, C., Antila, C., Mutvei, A., Imanishi, S.Y., Holmberg, J., Jin, S., Eriksson, J.E., Lendahl, U., Sahlgren, C.M.   +12 more
openaire   +2 more sources

The role of NOTCH2 gene in human malignant glial brain tumours [PDF]

, 2008
Background: Glioblastoma multiforme (GBM), astrocytoma (A) and oligodendroglioma (OG) are the neoplasms of the glial lineage in the Central Nervous System (CNS).
Sivasankaran, Balasubramanian
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mathematical analysis of the effect of portal vein cells on biliary epithelial cell differentiation through the Delta-Notch signaling pathway

BMC Research Notes, 2021
Objective The Delta-Notch signaling pathway induces fine-grained patterns of differentiation from initially homogeneous progenitor cells in many biological contexts, including Drosophila bristle formation, where mathematical modeling reportedly suggests ...
Masaharu Yoshihara, Teppei Nishino, Manoj Kumar Yadav, Akihiro Kuno, Takeshi Nagata, Hiroyasu Ando, Satoru Takahashi   +6 more
doaj   +1 more source

Nuclear βII-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling [PDF]

Cancer Research, 2004
Abstract The Notch signal pathway plays important roles in proliferation, apoptosis, and differentiation. Abnormalities in Notch signaling are linked to many human diseases. After ligand binding, Notch signaling is activated through the cleavage of Notch receptors to release and translocate the Notch intracellular domain into the nucleus.
Tien-Shun, Yeh, Rong-Hong, Hsieh, Shing-Chuan, Shen, Shwu-Huey, Wang, Min-Jen, Tseng, Chwen-Ming, Shih, Jing-Jer, Lin   +6 more
openaire   +2 more sources

Selective targeting of NOTCH-1 for therapeutic purposes in xenograft models of T-acute lymphoblastic leukemia [PDF]

, 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an heterogeneous disease, characterized by several genetic alterations and polymorphic clinical features both in children and adults.
Agnusdei, Valentina
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Mammalian NOTCH Receptor Activation and Signaling Protocols

, 2022
The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both developmental and adult stages in most animals. The NOTCH signaling pathway appears to be very simple but the existence of several receptors and ligands, their posttranslational modifications, their ...
Nueda Sanz, María Luisa, Baladrón García, Victoriano   +1 more
openaire   +3 more sources

Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor Corepressor [PDF]

Molecular and Cellular Biology, 2005
Hey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling. Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR).
Borja, Belandia, Sue M, Powell, Juana M, García-Pedrero, Marjorie M, Walker, Charlotte L, Bevan, Malcolm G, Parker   +5 more
openaire   +3 more sources

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]

, 2013
The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn, Rothman, A.M.K., Gray, Caroline, Haase, A., Haase, Andrea, Novodvorsky, P., Rothman, Alexander M K, Van Eeden, Fredericus J. M., Gering, Martin, Crossman, D.C., Chico, Timothy J. A., Watson, O., Crossman, David C, Chico, Timothy J A, Gering, M., Rothman, Alexander M. K., Crossman, David C., Novodvorsky, Peter, Lawrie, A., McMahon, K., Van Eeden, Fredericus J M, Lawrie, Allan, Van Eeden, F.J.M., Chico, T.J.A., Watson, Oliver, Gray, C.   +25 more
core   +1 more source