Results 1 to 10 of about 1,406,843 (290)
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers. [PDF]
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
doaj +10 more sources
In vivo analysis of the Notch receptor S1 cleavage.
PLoS ONE, 2009 A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake +4 more
doaj +7 more sources
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]
Cell Research, 2014 Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Urban Lendahl +2 more
exaly +4 more sources
Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway [PDF]
BMC Biology, 2022 Background Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway.
Björn Schnute +4 more
doaj +2 more sources
Cell Reports, 2023 Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian +5 more
doaj +3 more sources
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand. [PDF]
PLoS ONE, 2016 Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated
Maxwell Greene +5 more
doaj +4 more sources
Exploiting the Notch pathway in HTLV-1–driven adult T-cell leukemia/lymphoma: a mini-review [PDF]
Annals of HematologyHuman T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and several inflammatory disorders. Despite extensive research, the molecular mechanisms underlying HTLV-1 pathogenesis remain incompletely ...
Mohammad Mehdi Akbarin +2 more
doaj +2 more sources
Biomolecules, 2021 The Notch signaling pathway is pivotal to cellular differentiation. Activation of this pathway involves proteolysis of the Notch receptor and the release of the biologically active Notch intracellular domain, acting as a transcriptional co-activator of ...
Anja C. Nagel +3 more
doaj +1 more source
Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands.
Laura Gragnani +3 more
openaire +4 more sources
Frontiers in Genetics, 2023 Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng +6 more
doaj +1 more source