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The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
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Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models. [PDF]
PLoS ONE, 2012 The ability of Notch signaling to regulate T helper cell development and differentiation has been widely accepted. Fringe, O-fucose-β1,3-N-acetylglucosaminyltransferases modulate Notch receptor expression and promote the Notch signaling pathway through ...
Wen Gu, Weiguo Xu, Tao Ding, Xuejun Guo
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PLoS Computational BiologyThe ubiquitous Notch receptor signalling network is essential for tissue growth and maintenance. Operationally, receptor activity is regulated by two principal, counterposed mechanisms: intercellular Notch transactivation triggered by interactions ...
Daipeng Chen +4 more
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Molecular Therapy: Oncolytics, 2020 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and it is thus critical to identify novel molecular biomarkers of HCC prognosis and elucidate the molecular mechanisms underlying HCC progression.
Subbroto Kumar Saha +7 more
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An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules.
PLoS ONE, 2014 Notch family members were first identified as cell adhesion molecules by cell aggregation assays in Drosophila studies. However, they are generally recognized as signaling molecules, and it was unclear if their adhesion function was restricted to ...
Akihiko Murata +7 more
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OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
PLoS Biology, 2008 Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, suggesting possible functional complexities.
Hidetoshi Komatsu +10 more
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A role for actomyosin contractility in Notch signaling
BMC Biology, 2019 Background Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition.
Ginger L. Hunter +5 more
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PLoS ONE, 2010 BackgroundThe Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information is essential for gaining insight
Deborah F Kelly +5 more
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Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]
PLoS ONE, 2013 The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos +5 more
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Cell Regeneration, 2012 Background Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic ...
Yin Wenguang +7 more
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