Results 31 to 40 of about 98,277 (259)
Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells
Cells, 2019 Bone morphogenetic protein (BMP) and Notch signaling are critical for endothelial cell (EC) differentiation in vascular development. Recent studies have shown that excess BMP activity induces Notch signaling in cerebral ECs resulting in arteriovenous ...
Xiuju Wu +8 more
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Competition in notch signaling with cis enriches cell fate decisions.
PLoS ONE, 2014 Notch signaling is involved in cell fate choices during the embryonic development of Metazoa. Commonly, Notch signaling arises from the binding of the Notch receptor to its ligands in adjacent cells driving cell-to-cell communication.
Pau Formosa-Jordan, Marta Ibañes
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Cis-interactions between Notch and its ligands block ligand-independent Notch activity
eLife, 2014 The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate
William Hunt Palmer +2 more
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Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing. [PDF]
PLoS ONE, 2009 Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity.
Andrew K Shepherd +2 more
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eLife, 2017 Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation by ...
Graham J Britton +12 more
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CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells
Frontiers in Immunology, 2020 Notch signaling provides an important cue in the mammalian developmental process. It is a key player in T cell development and function. Notch ligands such as Delta-like ligands (DLL) 1, 3, 4, and JAG1, 2 can impact Notch signaling positively or ...
Ankita Mitra +13 more
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Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
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Therapeutic antibody targeting of individual Notch receptors [PDF]
Nature, 2010 The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan, Wu +23 more
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Estradiol meets Notch signaling in developing neurons
Frontiers in Endocrinology, 2011 The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis and neurite development in the nervous system.
Maria-Angeles eArevalo +5 more
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The Challenge of Targeting Notch in Hematologic Malignancies
Frontiers in Pediatrics, 2014 Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T
Fiorela N Hernandez Tejada +2 more
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