Results 51 to 60 of about 1,406,843 (290)

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

eLife, 2015
Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon   +18 more
doaj   +1 more source

Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. [PDF]

PLoS ONE, 2014
To determine the efficacy of perivascular delivery of Notch 1 siRNA in preventing injury-induced arterial remodeling.Carotid artery ligation was performed to induce arterial remodeling. After 14 days, morphometric analysis confirmed increased vSMC growth
Eileen M Redmond, Weimin Liu, Katie Hamm, Ekaterina Hatch, Paul A Cahill, David Morrow   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development

Scientific Reports, 2020
Organ cell diversity depends on binary cell-fate decisions mediated by the Notch signalling pathway during development and tissue homeostasis. A clear example is the series of binary cell-fate decisions that take place during asymmetric cell divisions ...
Ignacio Medina-Yáñez, Gonzalo H. Olivares, Franco Vega-Macaya, Marek Mlodzik, Patricio Olguín   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]

, 2005
In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core   +1 more source

Notch is a ligand of Draper mediating spermatogonia cell death

Nature Communications
Notch signalling is traditionally mediated through direct interaction between the Notch receptor and its transmembrane ligands, presented on the surface of adjacent cells.
Heba Abo Romi, Neven Serhan, Lilach Porat-Kuperstein, Hila Toledano   +3 more
doaj   +1 more source

Notch Signaling Pathway Is Activated by Sulfate Reducing Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
Sulfate Reducing Bacteria (SRB), usually rare residents of the gut, are often found in increased numbers (called a SRB bloom) in inflammatory conditions such as Inflammatory Bowel Disease (IBD), pouchitis, and periodontitis.
Sudha B. Singh, Cristina N. Coffman, Amanda Carroll-Portillo, Matthew G. Varga, Henry C. Lin, Henry C. Lin   +5 more
doaj   +1 more source

Therapeutic antibody targeting of individual Notch receptors [PDF]

Nature, 2010
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan, Wu, Carol, Cain-Hom, Lisa, Choy, Thijs J, Hagenbeek, Gladys P, de Leon, Yongmei, Chen, David, Finkle, Rayna, Venook, Xiumin, Wu, John, Ridgway, Dorreyah, Schahin-Reed, Graham J, Dow, Amy, Shelton, Scott, Stawicki, Ryan J, Watts, Jeff, Zhang, Robert, Choy, Peter, Howard, Lisa, Kadyk, Minhong, Yan, Jiping, Zha, Christopher A, Callahan, Sarah G, Hymowitz, Christian W, Siebel   +23 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source