Results 71 to 80 of about 1,406,843 (290)
Expression of Notch Receptors and Ligands in the Adult Gut [PDF]
Journal of Histochemistry & Cytochemistry, 2004 The Notch signaling pathway has become recognized as a vitally important pathway in regulating proliferative/differentiative decisions and cell fate. To explore the involvement of the Notch pathway in adult gut, we investigated the expression of Notch receptors and their ligands by Northern blotting and in situ hybridization.
Sander, G., Powell, B.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules.
PLoS ONE, 2014 Notch family members were first identified as cell adhesion molecules by cell aggregation assays in Drosophila studies. However, they are generally recognized as signaling molecules, and it was unclear if their adhesion function was restricted to ...
Akihiko Murata +7 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and it is thus critical to identify novel molecular biomarkers of HCC prognosis and elucidate the molecular mechanisms underlying HCC progression.
Subbroto Kumar Saha +7 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
The promising inhibition of the joint embriyonic period in the cancer stem cells and notch pathway
Cerrahpaşa Medical Journal, 2014 Objectives: The Notch signaling plays role to provide determining of cell fate and surviving of stem cell in the embryonic and postnatal development. The retardation effects of Notch in adult acts as oncogene or tumor suppressor gene.
Gülperi Öktem +6 more
doaj +1 more source
Nuclear βII-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling [PDF]
Cancer Research, 2004 Abstract The Notch signal pathway plays important roles in proliferation, apoptosis, and differentiation. Abnormalities in Notch signaling are linked to many human diseases. After ligand binding, Notch signaling is activated through the cleavage of Notch receptors to release and translocate the Notch intracellular domain into the nucleus.
Tien-Shun, Yeh +6 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
PLoS Biology, 2008 Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, suggesting possible functional complexities.
Hidetoshi Komatsu +10 more
doaj +1 more source
Mammalian NOTCH Receptor Activation and Signaling Protocols
, 2022 The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both developmental and adult stages in most animals. The NOTCH signaling pathway appears to be very simple but the existence of several receptors and ligands, their posttranslational modifications, their ...
Nueda Sanz, María Luisa +1 more
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