Control of Notch-ligand endocytosis by ligand-receptor interaction [PDF]
Development, 2010 In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and ligand-receptor interaction remains poorly understood. To study the specific role of ligand-receptor interaction, we identified a missense mutant of the Notch ligand Jagged1 (Nodder, Ndr) that failed ...
Hansson, E. M. +10 more
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The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]
, 2013 Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
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The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited anti-tumor efficacy because of dose-limiting toxicities in normal tissues.
Judith Hounjet, Marc Vooijs
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Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
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GIT1 protects against breast cancer growth through negative regulation of Notch
Nature Communications, 2022 Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER-
Songbai Zhang +16 more
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The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. [PDF]
PLoS ONE, 2012 The proteolytic activity of Furin responsible for processing full length Notch-1 (p300) plays a critical role in Notch signaling. The amplitude and duration of Notch activity can be regulated at various points in the pathway, but there has been no report
Yong-Chao Ma +8 more
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Notch receptor and Notch ligand expression in developing avian cartilage [PDF]
Journal of Anatomy, 2009 AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams +4 more
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Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis [PDF]
Experimental Hematology, 2000 Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
N, Singh +3 more
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Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
mBio, 2022 Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch.
LaNisha L. Patterson +7 more
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A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells
Frontiers in Immunology, 2018 The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies.
Martin Peter Steinbuck, Susan Winandy
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