Results 11 to 20 of about 98,277 (259)
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers. [PDF]
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
doaj +6 more sources
In vivo analysis of the Notch receptor S1 cleavage.
PLoS ONE, 2009 A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake +4 more
doaj +7 more sources
Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway [PDF]
BMC Biology, 2022 Background Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway.
Björn Schnute +4 more
doaj +2 more sources
Cell Reports, 2023 Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian +5 more
doaj +3 more sources
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand. [PDF]
PLoS ONE, 2016 Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated
Maxwell Greene +5 more
doaj +4 more sources
Biomolecules, 2021 The Notch signaling pathway is pivotal to cellular differentiation. Activation of this pathway involves proteolysis of the Notch receptor and the release of the biologically active Notch intracellular domain, acting as a transcriptional co-activator of ...
Anja C. Nagel +3 more
doaj +1 more source
Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands.
Laura Gragnani +3 more
openaire +4 more sources
Frontiers in Genetics, 2023 Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng +6 more
doaj +1 more source
Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
openaire +2 more sources
Notch receptor and Notch ligand expression in developing avian cartilage [PDF]
Journal of Anatomy, 2009 AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams +4 more
openaire +2 more sources