Results 21 to 30 of about 98,277 (259)

GIT1 protects against breast cancer growth through negative regulation of Notch

Nature Communications, 2022
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER-
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén   +16 more
doaj   +1 more source

Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis [PDF]

Experimental Hematology, 2000
Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
N, Singh, R A, Phillips, N N, Iscove, S E, Egan   +3 more
openaire   +2 more sources

The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. [PDF]

PLoS ONE, 2012
The proteolytic activity of Furin responsible for processing full length Notch-1 (p300) plays a critical role in Notch signaling. The amplitude and duration of Notch activity can be regulated at various points in the pathway, but there has been no report
Yong-Chao Ma, Chong Shi, Yao-Nan Zhang, Lan-Ge Wang, Hao Liu, Hong-Ti Jia, Yu-Xiang Zhang, Fazlul H Sarkar, Ze-Sheng Wang   +8 more
doaj   +1 more source

The Role of Notch Receptors in Transcriptional Regulation [PDF]

Journal of Cellular Physiology, 2015
Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and homeostasis of adult tissues. Aberrant Notch signaling (both hyper‐ and hypoactive) is implicated in a number of human developmental disorders and many cancers.
Hongfang, Wang, Chongzhi, Zang, X Shirley, Liu, Jon C, Aster   +3 more
openaire   +2 more sources

Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

mBio, 2022
Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch.
LaNisha L. Patterson, Thangam Sudha Velayutham, Caitlan D. Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W. McBride   +7 more
doaj   +1 more source

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells

Frontiers in Immunology, 2018
The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies.
Martin Peter Steinbuck, Susan Winandy
doaj   +1 more source

The NOTCH receptor and its ligands

Trends in Cell Biology, 1997
An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming, K, Purcell, S, Artavanis-Tsakonas   +2 more
openaire   +2 more sources

Diversity in Notch ligand-receptor signaling interactions

eLife, 2023
Abstract The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulated by ...
Rachael Kuintzle, Leah A. Santat, Michael B. Elowitz   +2 more
openaire   +4 more sources

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. [PDF]

PLoS Biology, 2010
Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble ...
Julien Moretti, Patricia Chastagner, Stefano Gastaldello, Sara F Heuss, Annette M Dirac, René Bernards, Maria G Masucci, Alain Israël, Christel Brou   +8 more
doaj   +1 more source

Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models

Frontiers in Physiology, 2020
Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the emergent spatiotemporal patterning in a tissue through ligand-receptor ...
Federico Bocci, José Nelson Onuchic, José Nelson Onuchic, José Nelson Onuchic, José Nelson Onuchic, Mohit Kumar Jolly   +5 more
doaj   +1 more source