Results 1 to 10 of about 110,460 (323)

Isolation and Molecular Characterization of Spermatogonial Stem Cells in Nile Tilapia [PDF]

Journal of Bioscience and Applied Research, 2017
The identification and isolation of spermatogonial stem cells in Nile tilapia is crucial to the development of high-quality transplantation techniques as well as to understand the regulation of spermatogonia in vivo.
Heba Allah Elbaghdady, Sayed Areida, Hany Marei, Hamada Salem   +3 more
doaj   +1 more source

Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway

Open Life Sciences, 2020
Multiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis
Zhang Yongtian, Zhao Dandan, Li Shumei, Xiao Meng, Zhou Hongjing, Yang Shuige, Hao Yunliang, Dong Shasha   +7 more
doaj   +1 more source

NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia

Frontiers in Oncology, 2022
NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).
Jennifer Edelmann
doaj   +1 more source

Notch1 signaling in the hepatic microcirculation and chronic liver disease [PDF]

, 2013
The Notch signaling pathway is an evolutionary conserved pathway that plays essential roles during vascular development and in the regulation of normal and pathological angiogenesis in the adulthood.
Rothweiler, Sonja
core   +1 more source

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

Science, 2011
The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide.
N. Agrawal, M. Frederick, C. Pickering, C. Bettegowda, Kyle Chang, Ryan J Li, C. Fakhry, T. Xie, Jiexin Zhang, Jing Wang, Nianxiang Zhang, A. El-Naggar, S. Jasser, J. Weinstein, L. Treviño, J. Drummond, D. Muzny, Yuanqing Wu, L. Wood, R. Hruban, W. Westra, W. Koch, J. Califano, R. Gibbs, D. Sidransky, B. Vogelstein, V. Velculescu, N. Papadopoulos, D. Wheeler, K. Kinzler, J. Myers   +30 more
semanticscholar   +1 more source

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

Nature Communications, 2020
BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies.
Kai Miao, J. Lei, Monica V. Valecha, Aiping Zhang, Jun Xu, Lijian Wang, Xueying Lyu, Si Chen, Zhengqiang Miao, Xin Zhang, Sek Man Su, Fangyuan Shao, Barani Kumar Rajendran, Jiaolin Bao, Jianming Zeng, Heng Sun, Ping-Tzu Chen, Kaeling Tan, Qiang Chen, K. H. Wong, Xiaoling Xu, C. Deng   +21 more
semanticscholar   +1 more source

Inhibition of NOTCH1 signaling in tumor-initiating cells overcomes chemoresistance and promotes apoptosis [PDF]

Archives of Biological Sciences, 2021
The Notch signaling pathway is an evolutionarily conserved pathway essential for regulation of cell development and differentiation. Upregulation and activation of Notch signaling enhances the oncogenic potential of cancer cells through ...
Rui Yang, Gang Zhan, Jun Zhou, Weidong Jin, Hui Jiang   +4 more
doaj   +1 more source

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Nature Communications, 2020
Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant ...
Huimin Jiang, Chen Zhou, Zhen Zhang, Qiong Wang, Huimin Wei, W. Shi, Jianjun Li, Zhaoyang Wang, Yang Ou, Wenhao Wang, Hang Wang, Quansheng Zhang, Wei Sun, Peiqing Sun, Shuang Yang   +14 more
semanticscholar   +1 more source

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [PDF]

, 2014
During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene ...
Dale, J. Kim, Bone, Robert A., Appleton, Paul L., Wiedermann, Guy, Ferjentsik, Zoltan, Murray, Philip J., Bailey, Charlotte S. L., Maroto, Miguel   +7 more
core   +1 more source

Notch1 in Cancer Therapy: Possible Clinical Implications and Challenges

Molecular Pharmacology, 2020
The Notch family consists of four highly conserved transmembrane receptors. The release of the active intracellular domain requires the enzymatic activity of γ-secretase.
L. Gharaibeh, Nirmeen Elmadany, Kholoud Alwosaibai, W. Alshaer   +3 more
semanticscholar   +1 more source