Results 1 to 10 of about 10,317 (177)

List of differentially expressed genes in LCM hepatic regions-derived from NHPs with moderate anti-DLL4-associated SD (severity score 2, SD 2) (n = 6) compared to LCM hepatic regions-derived from NHPs without anti-DLL4-associated SD (severity score 0, SD 0) (n = 6).

, 2018
List of differentially expressed genes in LCM hepatic regions-derived from NHPs with moderate anti-DLL4-associated SD (severity score 2, SD 2) (n = 6) compared to LCM hepatic regions-derived from NHPs without anti-DLL4-associated SD (severity score 0, SD
Jennifer Vogt (5349653), Rupal Desai (111308), Patrick Dicker (5349650), Annette T. Byrne (3701101), John W. M. Martens (146698), Eric P. van der Stok (5349665), Gary Cain (2803033), Jens Brodbeck (305955), Dale Stevens (5349662), Cornelis Verhoef (446919), Monika A. Jarzabek (3701089), Priti S. Hegde (5349659), Jacqueline M. Tarrant (5349656), William R. Proctor (5349647), Rajiv Raja (111316)   +14 more
core   +1 more source

miR-153-3p inhibits renal cancer cell growth and angiogenesis by negatively regulating the DLL4-mediated Notch pathway

徐州医科大学学报
Objective To investigate the effects of miR-153-3p on cell proliferation and angiogenesis in renal cell carcinoma (RCC) and its underlying mechanism.Methods The expression of miR-153-3p in RCC adjacent and tumor tissues was analyzed based on the TCGA ...
WAN Xiaoxiang, XU Yaozong, ZHANG Jun, WANG Yang, SHI Guowei, WANG Xilong   +5 more
doaj   +1 more source

The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.

PLoS ONE, 2012
BackgroundIn mouse embryos, homozygous or heterozygous deletions of the gene encoding the Notch ligand Dll4 result in early embryonic death due to major defects in endothelial remodeling in the yolk sac and embryo.
Ricardo Laranjeiro, Isabel Alcobia, Hélia Neves, Andreia C Gomes, Pedro Saavedra, Catarina C Carvalho, António Duarte, António Cidadão, Leonor Parreira   +8 more
doaj   +1 more source

The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Journal of Investigative Surgery, 2020
Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline.
Chaoyang Qi, Yuting Lin, Dingsheng Lin
doaj   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

The delta-like ligand 4-notch signaling inhibits tumor angiogenesis but promotes tumor growth in primary glioblastoma: An immunohistochemical study

Glioma, 2018
Background: Delta-like ligand 4 (DLL4) is a key Notch ligand implicated in tumor angiogenesis. However, previous studies have shown that the DLL4-Notch signaling inhibits tumor angiogenesis but promotes tumor progression in primary glioblastoma.
Yao Chen, Zhi-Xiong Lin, Jin-Tao Chen, Ming-Cheng Zheng   +3 more
doaj   +1 more source

Effects of Dll4 in hematopoiesis.

, 2012
(A) Flow cytometry analysis of CD41 expression in WT, Dll4+/− and Dll4−/− EBs from day 3.5 to day 6 of differentiation. (B) Number of CFU-EryP; (C) CFU-definitive erythroid (EryD) and (D) total definitive CFUs (include CFU-EryD, -macrophage, -granulocyte,
Isabel Alcobia (171113), Catarina C. Carvalho (171135), António Duarte (109168), Leonor Parreira (171141), Pedro Saavedra (171130), António Cidadão (171139), Hélia Neves (171118), Andreia C. Gomes (171124), Ricardo Laranjeiro (171108)   +8 more
core   +1 more source

Schematic summary of findings on drug-induced SD based on current analyses in anti-DLL4-induced SD in NHP model and oxaliplatin +/- bev in CRLM patients.

, 2018
Anti-DLL4 and oxaliplatin can lead to dysregulation of NOTCH/VEGF signaling pathways genes in the LSECs. These changes in hepatic gene expression lead to alterations in vascular homeostasis and subsequently to LSEC dysfunction.
Jennifer Vogt (5349653), Rupal Desai (111308), Patrick Dicker (5349650), Annette T. Byrne (3701101), John W. M. Martens (146698), Eric P. van der Stok (5349665), Gary Cain (2803033), Jens Brodbeck (305955), Dale Stevens (5349662), Cornelis Verhoef (446919), Monika A. Jarzabek (3701089), Priti S. Hegde (5349659), Jacqueline M. Tarrant (5349656), William R. Proctor (5349647), Rajiv Raja (111316)   +14 more
core   +1 more source

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

eLife, 2020
Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority
Ken-ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi   +7 more
doaj   +1 more source

Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. [PDF]

PLoS ONE, 2013
The Notch pathway plays a role in the processes of cell proliferation, differentiation, and apoptosis, which affect the development and function of various organs.
Huei-Mei Huang, George Hsiao, Chia-Kwung Fan, Chu-Lun Lin, Sy-Jye Leu, Bor-Luen Chiang, Yueh-Lun Lee   +6 more
doaj   +1 more source