Results 31 to 40 of about 9,075 (179)

Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis [PDF]

Circulation Research, 2020
Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ has long been considered to be responsible for vascular barrier in central nervous system, suppressed transcytosis in endothelial cells is now emerging as a complementary mechanism ...
Jee Myung Yang, Chan Soon Park, Soo Hyun Kim, Tae Wook Noh, Ju-Hee Kim, Seongyeol Park, Jingu Lee, Jang Ryul Park, Dohyun Yoo, Hyun Ho Jung, Hiroshi Takase, David T. Shima, Markus Schwaninger, Seungjoo Lee, Il-Kug Kim, Junyeop Lee, Yong-Sok Ji, Sangyong Jon, Wang-Yuhl Oh, Pilhan Kim, Akiyoshi Uemura, Young Seok Ju, Injune Kim   +22 more
openaire   +3 more sources

miR-153-3p inhibits renal cancer cell growth and angiogenesis by negatively regulating the DLL4-mediated Notch pathway

徐州医科大学学报
Objective To investigate the effects of miR-153-3p on cell proliferation and angiogenesis in renal cell carcinoma (RCC) and its underlying mechanism.Methods The expression of miR-153-3p in RCC adjacent and tumor tissues was analyzed based on the TCGA ...
WAN Xiaoxiang, XU Yaozong, ZHANG Jun, WANG Yang, SHI Guowei, WANG Xilong   +5 more
doaj   +1 more source

The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.

PLoS ONE, 2012
BackgroundIn mouse embryos, homozygous or heterozygous deletions of the gene encoding the Notch ligand Dll4 result in early embryonic death due to major defects in endothelial remodeling in the yolk sac and embryo.
Ricardo Laranjeiro, Isabel Alcobia, Hélia Neves, Andreia C Gomes, Pedro Saavedra, Catarina C Carvalho, António Duarte, António Cidadão, Leonor Parreira   +8 more
doaj   +1 more source

The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Journal of Investigative Surgery, 2020
Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline.
Chaoyang Qi, Yuting Lin, Dingsheng Lin
doaj   +1 more source

Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. [PDF]

PLoS ONE, 2011
Neo-blood vessel growth (angiogenesis), which may involve the activation of pre-existing endothelial cells (EC) and/or the recruitment of bone marrow-derived vascular precursor cells (BM-VPC), is essential for tumor growth.
Carla Real, Leonor Remédio, Francisco Caiado, Cátia Igreja, Cristina Borges, Alexandre Trindade, Perpétua Pinto-do-Ó, Hideo Yagita, Antonio Duarte, Sérgio Dias   +9 more
doaj   +1 more source

The delta-like ligand 4-notch signaling inhibits tumor angiogenesis but promotes tumor growth in primary glioblastoma: An immunohistochemical study

Glioma, 2018
Background: Delta-like ligand 4 (DLL4) is a key Notch ligand implicated in tumor angiogenesis. However, previous studies have shown that the DLL4-Notch signaling inhibits tumor angiogenesis but promotes tumor progression in primary glioblastoma.
Yao Chen, Zhi-Xiong Lin, Jin-Tao Chen, Ming-Cheng Zheng   +3 more
doaj   +1 more source

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

eLife, 2020
Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority
Ken-ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi   +7 more
doaj   +1 more source

Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. [PDF]

PLoS ONE, 2013
The Notch pathway plays a role in the processes of cell proliferation, differentiation, and apoptosis, which affect the development and function of various organs.
Huei-Mei Huang, George Hsiao, Chia-Kwung Fan, Chu-Lun Lin, Sy-Jye Leu, Bor-Luen Chiang, Yueh-Lun Lee   +6 more
doaj   +1 more source

CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells

The Journal of Pathology, EarlyView.
Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune populations such as tumour‐associated neutrophils can potentially impair the success of immunotherapy ...
Joanne M O'Rourke, Dean Kavanagh, Ayla O'Keeffe, Kylie Savoye, Kaiyi Yang, Daniel A Patten, Catherine E Willoughby, Josep M Llovet, Georgiana Neag, Helen L Reeves, Peter W Hewett, Neena Kalia, Tahir Shah, Yuk Ting Ma, Kelly Hunter, Joe Flint, Jack L McMurray, Owen Cain, Fabian Spill, Derek A Mann, Amy J Naylor, Victoria Heath, Christopher J Weston, Roy Bicknell, Shishir Shetty   +24 more
wiley   +1 more source

Anti-DLL4, a cancer therapeutic with multiple mechanisms of action

Vascular Cell, 2011
DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance ...
Gurney, Austin, Hoey, Timothy
openaire   +3 more sources