Results 11 to 20 of about 10,317 (177)
Journal of Ophthalmology, 2018 Background. Retina is the highest oxygen-demanding and vascularized tissue in the body. Retinal development and function require proper vascularization and blood vessel function and integrity.
Ivan Lobov, Natalia Mikhailova
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Endothelial cells regulate mesangial cells through the Dll4/Notch3 axis to participate in glomerular injury in lupus nephritis [PDF]
Frontiers in ImmunologyIntroductionIncreasing evidence suggests that microvascular dysregulation mediates mesangial cell (MC) alteration in the pathogenesis of LN (Lupus nephritis).
Haixia Guo +7 more
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Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine [PDF]
PeerJ, 2014 Reports have suggested that the two Notch ligands, Dll1 and Dll4, are indispensable to maintain the homeostasis of the intestinal epithelium. However, within the intestinal epithelium, the precise distribution of the cells that express those ligands at ...
Hiromichi Shimizu +11 more
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A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse [PDF]
Biology Open, 2018 Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces multiple proteolytic cleavage events culminating in the nuclear accumulation of the Notch ...
Alexander M. Herman +5 more
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Microvascular Research, 2008 The Notch ligand, Dll4, is essential for angiogenesis during embryonic vascular development and is involved in tumour angiogenesis. Several recent publications demonstrated that blockade of Dll4 signalling inhibits tumour growth, suggesting that it may ...
Richard C A Sainson +2 more
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Targeting DLL4 in Tumors Shows Preclinical Activity But Potentially Significant Toxicity
Future Oncology, 2010 Evaluation of: Yan M, Callahan CA, Beyer JC et al.: Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6-E7 (2010). Delta-like ligand 4 (DLL4) is a Notch ligand that is critical in the formation of a functional vascular network in tumors ...
Ji-Liang Li +2 more
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Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. [PDF]
PLoS ONE, 2011 Neo-blood vessel growth (angiogenesis), which may involve the activation of pre-existing endothelial cells (EC) and/or the recruitment of bone marrow-derived vascular precursor cells (BM-VPC), is essential for tumor growth.
Carla Real +9 more
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Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice. [PDF]
PLoS ONE, 2016 Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor.
Mike L J Jeurissen +13 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 OBJECTIVE: Bone morphogenetic protein-9 (BMP9)/activin-like kinase-1 and delta-like 4 (DLL4)/Notch promote endothelial quiescence, and we aim to understand mechanistic interactions between the 2 pathways.
Bahman Rostama +2 more
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iScience, 2022 Summary: Early Th17 responses are necessary to provide protection against Mycobacterium tuberculosis (Mtb). Mtb impedes Th17 polarization by restricting CD40 co-stimulatory pathway on dendritic cells (DCs).
Ana Beatriz Enriquez +6 more
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