Results 41 to 50 of about 110,460 (323)

Endothelial Notch1 Activity Facilitates Metastasis. [PDF]

Cancer Cell, 2017
Endothelial cells (ECs) provide angiocrine factors orchestrating tumor progression. Here, we show that activated Notch1 receptors (N1ICD) are frequently observed in ECs of human carcinomas and melanoma, and in ECs of the pre-metastatic niche in mice. EC N1ICD expression in melanoma correlated with shorter progression-free survival.
E. Wieland, J. Rodríguez-Vita, Sven S. Liebler, C. Mogler, Iris Moll, Stefanie E. Herberich, Elisa Espinet, E. Herpel, Amitai Menuchin, J. Chang-Claude, M. Hoffmeister, C. Gebhardt, H. Brenner, A. Trumpp, C. Siebel, M. Hecker, J. Utikal, D. Sprinzak, Andreas Fischer   +18 more
semanticscholar   +3 more sources

Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

BMC Cancer, 2022
Background Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in
Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno, Kenji Ishitsuka   +8 more
doaj   +1 more source

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. [PDF]

PLoS ONE, 2012
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in
Wenxue Ma, Alejandro Gutierrez, Daniel J Goff, Ifat Geron, Anil Sadarangani, Christina A M Jamieson, Angela C Court, Alice Y Shih, Qingfei Jiang, Christina C Wu, Kang Li, Kristen M Smith, Leslie A Crews, Neil W Gibson, Ida Deichaite, Sheldon R Morris, Ping Wei, Dennis A Carson, A Thomas Look, Catriona H M Jamieson   +19 more
doaj   +1 more source

Genetic testing for aortic valve stenosis

The EuroBiotech Journal, 2018
Aortic valve stenosis (AVS) is a congenital aortic defect in which the aortic lumen narrows due to thickening or calcification of the aortic valve without obstructing left ventricular outflow.
Rakhmanov Yeltay, Maltese Paolo Enrico, Zulian Alessandra, Paolacci Stefano, Beccari Tommaso, Dundar Munis, Bertelli Matteo   +6 more
doaj   +1 more source

-Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1.

Blood, 2020
Richter's transformation (RT) is an aggressive lymphoma which occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL-phase involving TP53, CDKN2A, MYC, and NOTCH1, however a
Vivien Kohlhaas, S. Blakemore, Mona Al-Maarri, N. Nickel, Martin Pal, A. Roth, N. Hövelmeyer, S. C. Schäfer, G. Knittel, P. Lohneis, M. Nikolic, J. Wiederstein, M. Franitza, Theodoros Georgomonolis, Nina Reinart, M. Herling, C. Herling, E. Hartmann, A. Rosenwald, W. Klapper, R. Büttner, R. Moia, D. Rossi, R. Boldorini, G. Gaidano, Lukas P. Frenzel, H. C. Reinhardt, Jens C. Brüning, M. Hallek, M. Krüger, M. Peifer, C. Pallasch, F. Wunderlich   +32 more
semanticscholar   +1 more source

Notch2 signaling in development and cancer [PDF]

, 2012
Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core   +1 more source

The Predominant Prognostic Significance of NOTCH1 Mutation Defined by Emulsion PCR in Chronic Lymphocytic Leukemia

Cancer Management and Research, 2021
Katarzyna Skórka,1 Michał Chojnacki,1 Marta Masternak,1 Agnieszka Karczmarczyk,1 Edyta Subocz,2 Ewa Wawrzyniak,3 Krzysztof Giannopoulos1,4 1Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland; 2Department of ...
Skórka K, Chojnacki M, Masternak M, Karczmarczyk A, Subocz E, Wawrzyniak E, Giannopoulos K   +6 more
doaj  

Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1

Molecular Cancer, 2019
N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year.
Chaohui Gu, Zhiyu Wang, Naichun Zhou, Guanru Li, Yiping Kou, Yang Luo, Yidi Wang, Jinjian Yang, Fengyan Tian   +8 more
semanticscholar   +1 more source

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

eLife, 2020
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels.
V. Caolo, M. Debant, Naima Endesh, T. Futers, Laeticia Lichtenstein, Fiona Bartoli, Greg Parsonage, E. Jones, D. Beech   +8 more
semanticscholar   +1 more source

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region

Clinical and Translational Medicine, 2020
Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones and nonhistone chromatin factors and have been classified as curative ...
Zhennan Tao, Xuetao Li, Hao Wang, Guangliang Chen, Zibin Feng, Yue Wu, Haoran Yin, Guozheng Zhao, Zhitong Deng, Chaohui Zhao, Yanyan Li, Ting Sun, Youxin Zhou   +12 more
doaj   +1 more source