Results 61 to 70 of about 110,460 (323)

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2

Journal of Biological Chemistry, 2020
Notch signaling is a cellular pathway regulating cell-fate determination and adult tissue homeostasis. Little is known about how canonical Notch ligands or Fringe enzymes differentially affect NOTCH1 and NOTCH2.
S. Kakuda, R. Lopilato, Atsuko Ito, R. Haltiwanger   +3 more
semanticscholar   +1 more source

T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology

Molecular & Cellular Oncology, 2018
Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype ...
Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García   +5 more
doaj   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach

, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

core   +1 more source

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Science Translational Medicine, 2019
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target. HAlting liver fibrosis Hepatic stellate cells (HSCs) play a key role in liver fibrosis, a process marked by ...
Y. Yang, M. Noureddin, Cheng Liu, Koichiro Ohashi, S. Kim, Divya Ramnath, E. Powell, M. Sweet, Y. Roh, I‐Fang Hsin, N. Deng, Zhenqiu Liu, Jiurong Liang, E. Mena, D. Shouhed, R. Schwabe, D. Jiang, Shelly C. Lu, P. Noble, E. Seki   +19 more
semanticscholar   +1 more source

Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain [PDF]

Journal of Biological Chemistry, 2003
The cell fate determinant Numb influences developmental decisions by antagonizing the Notch signaling pathway. However, the underlying molecular mechanism of this inhibition is poorly understood. Here we report that the mammalian Numb protein promotes the ubiquitination of membrane-bound Notch1 receptor.
Melanie A, McGill, C Jane, McGlade
openaire   +2 more sources

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Stromal cells and pro-inflammatory cytokines play key roles in promoting the aggressiveness of triple-negative breast cancers (TNBC; Basal/Basal-like).
Yulia Liubomirski, Shalom Lerrer, Tsipi Meshel, Dina Morein, Linor Rubinstein-Achiasaf, David Sprinzak, Stefan Wiemann, Cindy Körner, Marcelo Ehrlich, Adit Ben-Baruch   +9 more
doaj   +1 more source

Clinical and molecular characterization of early T-cell precursor leukemia : a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

, 2012
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome.
Hoelzer, Dieter, Farhadi-Sartangi, Nasrin, Schlee, Cornelia, Hofmann, Wolf-Karsten, Thiel, Eckhard, Burmeister, Thomas, Neumann, Martin, Thibaut, Julia, Gökbuget, Nicola, Heesch, Sandra, Schwartz, Stefan, Benlasfer, Ouidad, Baldus, Claudia   +12 more
core   +1 more source

Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Journal of experimental & clinical cancer research : CR, 2019
Glioma initiating cells (GICs), also known as glioma stem cells (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation and tumor initiation.
L. Yi, Xingchen Zhou, Tao Li, Peidong Liu, Long Hai, Luqing Tong, Haiwen Ma, Zhennan Tao, Yang Xie, Chen Zhang, Sheng-ping Yu, Xuejun Yang   +11 more
semanticscholar   +1 more source

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice [PDF]

Proceedings of the National Academy of Sciences, 2006
To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1 IC ) causes development of lactation ...
Apostolos, Klinakis, Matthias, Szabolcs, Katerina, Politi, Hippokratis, Kiaris, Spyros, Artavanis-Tsakonas, Argiris, Efstratiadis   +5 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source