Results 51 to 60 of about 110,460 (323)

G protein‐coupled oestrogen receptor promotes cell growth of non‐small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling

Journal of Cellular and Molecular Medicine, 2020
Results from various studies reveal that the role of G protein‐coupled oestrogen receptor (GPER) is cancer‐context dependent, and the function of GPER in non–small‐cell lung cancer (NSCLC) is still unclear.
Yisong Shen, Chong Li, Lin Zhou, Jian-an Huang   +3 more
semanticscholar   +1 more source

Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia

Journal of Integrative Neuroscience
Background: Ischemic stroke is the most common form of stroke and the second most common cause of death and incapacity worldwide. Its pathogenesis and treatment have been the focus of considerable research.
Wenjuan Li, Huachun Miao, Zeyin Nie, Feng Wu, Huaibin Li   +4 more
doaj   +1 more source

An unexpected tumor suppressor role for VAV1a

Molecular & Cellular Oncology, 2018
RHO GDP/GTP exchange factors, including VAV1, are considered key protumorigenic factors. Against this paradigm, we have found that VAV1 plays tumor suppressor roles by buffering NOTCH1 signals in thymocytes.
Xosé R. Bustelo, L. Francisco Lorenzo-Martín, Myriam Cuadrado, Isabel Fernández-Pisonero, Javier Robles-Valero   +4 more
doaj   +1 more source

Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells [PDF]

, 2020
Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), particularly in NOTCH1-mutated patients.
Aymerich, Marta, Villamor, Neus, Lee-Vergés, Eriong, López-Guillermo, Armando, Colomer, Dolors, Eriong Lee-Vergés, Laia Rosich, Giménez Carabaza, Neus, Ariadna Giró, Jocabed Roldán, Xose S. Puente, Neus Giménez, García-León, María J., Silkenstedt, Elisabeth, Marta Aymerich, López Guillermo, Armando, María L. Toribio, Toribio, María L., González-Farré, Blanca, Campo Güerri, Elias, Colomer Pujol, Dolors, Delgado, Julio, Neus Villamor, Sílvia Xargay-Torrent, Rosich, Laia, Aymerich Gregorio, Marta, Campos, Elías, Roldán, Jocabed, Dolors Colomer, María J. García-León, Mónica López-Guerra, García León, María J., Elisabeth Silkenstedt, López-Guerra, Mónica, Toribio, María Luisa, Delgado, Julio (Delgado González), Julio Delgado, Patricia Fuentes, Fuentes, Patricia, Villamor i Casas, Neus, Blanca González-Farré, Giró, Ariadna, Armando López-Guillermo, Elias Campo, Xargay-Torrent, Sílvia, Xargay i Torrent, Sílvia, Giménez, Neus, Puente, Xose S., González Farré, Blanca   +48 more
core   +1 more source

Nrf2 promotes breast cancer cell migration via up‐regulation of G6PD/HIF‐1α/Notch1 axis

Journal of Cellular and Molecular Medicine, 2019
Abnormal metabolism of tumour cells is closely related to the occurrence and development of breast cancer, during which the expression of NF‐E2‐related factor 2 (Nrf2) is of great significance. Metastatic breast cancer is one of the most common causes of
Hong-Sheng Zhang, Zhong-guo Zhang, Guangyuan Du, Hong-Liang Sun, Hui-Yun Liu, Z. Zhou, Xiao-Meng Gou, Xihao Wu, Xiao-ying Yu, Ying-Hui Huang   +9 more
semanticscholar   +1 more source

Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts

International Journal of Molecular Sciences, 2020
Keloid is a representative chronic fibroproliferative condition that occurs after tissue injury. Emerging evidence showed that activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in the pro-inflammatory ...
Seongju Lee, Sun Kyeon Kim, Hyungsun Park, Y. Lee, S. Park, Kyung Jae Lee, D. Lee, Hoon Kang, J. Kim   +8 more
semanticscholar   +1 more source

BCAT1 is a NOTCH1 target and sustains the oncogenic function of NOTCH1

Haematologica
High levels of branched-chain amino acid (BCAA) transaminase 1 (BCAT1) have been associated with tumor aggressiveness and drug resistance in several cancer types. Nevertheless, the mechanistic role of BCAT1 in T-cell acute lymphoblastic leukemia (T-ALL) remains uncertain.
Tosello, Valeria, Di Martino, Ludovica, Papathanassiu, Adonia E., Dalla Santa, Silvia, Pizzi, Marco, Mussolin, Lara, Liu, Jingjing, Van Vlierberghe, Pieter, Piovan, Erich   +8 more
openaire   +3 more sources

Molecular Characterization of Notch1 Positive Progenitor Cells in the Developing Retina. [PDF]

PLoS ONE, 2015
The oscillatory expression of Notch signaling in neural progenitors suggests that both repressors and activators of neural fate specification are expressed in the same progenitors.
Galina Dvoriantchikova, Isabel Perea-Martinez, Steve Pappas, Ariel Faye Barry, Dagmara Danek, Xenia Dvoriantchikova, Daniel Pelaez, Dmitry Ivanov   +7 more
doaj   +1 more source

The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus

Dental Research Journal, 2023
Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi, Fatemeh Saeid Nematpour, Nooshin Mohtasham, Farnaz Mohajertehran   +3 more
doaj   +1 more source

Hydroxytyrosol protects isoproterenol-induced myocardial infarction through activating notch signaling [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In this investigation, the protective effects of hydroxytyrosol (HT) administered prior to myocardial infarction in rats were examined, with a particular focus on its potential roles within the Notch pathway.Materials and Methods: The ...
Elif Onat, Ahmet Türk, Nevin Kocaman, Serhat Hançer, Solmaz Susam, Ali Parlar, Selin Turhan, Mehmet Ozer   +7 more
doaj   +1 more source