Results 31 to 40 of about 110,460 (323)
Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling [PDF]
Cancer Biology & Therapy, 2009 The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties. Suggesting a functional relationship, each gene can act to promote or suppress tumorigenesis in a context-dependent manner, and alteration of KLF4 or Notch pathway genes in mice gives rise to similar phenotypes. Activation of a conditional allele of
Zhaoli, Liu +7 more
openaire +2 more sources
Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling [PDF]
BMB Reports, 2015 Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus.
Lee, Hye-Jin +2 more
openaire +2 more sources
Open Medicine, 2023 Radiotherapy resistance is a challenge for colorectal cancer (CRC) treatment. Circular RNAs (circRNAs) play vital roles in the occurrence and development of CRC.
Wang Ximin +3 more
doaj +1 more source
Prognostic value of NOTCH1 and OCT4 in gastric carcinoma
Indian Journal of Pathology and Microbiology, 2022 Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim +3 more
doaj +1 more source
Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer
Cell Death and Disease, 2021 Oncogenic signaling pathway reprograms cancer cell metabolism to promote aerobic glycolysis in favor of tumor growth. The ability of cancer cells to evade immunosurveillance and the role of metabolic regulators in T-cell functions suggest that oncogene ...
M. Xie, Xin-ge Fu, K. Jiang
semanticscholar +1 more source
Cell Communication and Signaling, 2022 Background Notch signaling is highly conserved and critically involved in cell differentiation, immunity, and survival. Activation of the Notch pathway modulates immune cell functions during the inflammatory response.
Dongwei Xu +8 more
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Human dental stem cells (DSCs) are excellent sources of cells for treating dental and craniofacial diseases. However, the mechanisms regulating DSC osteogenic differentiation are still unclear. In this study, we aimed to determine the role of
Xinyuan Zhao +4 more
doaj +1 more source
Optogenetic control of NOTCH1 signaling
Cell Communication and Signaling, 2022 Abstract The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases. NOTCH1 plays a key role in breast cancer progression by increasing proliferation, maintenance of cancer stem cells, and impairment of cell death ...
Joanna Kałafut +6 more
openaire +3 more sources
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature.
American Journal of Physiology - Cell Physiology, 2021 The Notch pathway regulates complex patterning events in many species and is critical for the proper formation and function of the vasculature. Despite this importance, how the various components of the Notch pathway work in concert is still not well ...
Juliann B. Tefft +5 more
semanticscholar +1 more source
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]
, 2010 Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Mazur Pawel K. +40 more
core +1 more source