Results 21 to 30 of about 110,460 (323)

Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME

Journal of Experimental & Clinical Cancer Research
Background Immune checkpoint inhibitors (ICI) have dramatically improved the life expectancy of patients with metastatic melanoma. However, about half of the patient population still present resistance to these treatments. We have previously shown Notch1
Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M. LaPorte, Vijay S. Thakur, Brian Flores, Valentina Caicedo, Chioma G. E. Ajaegbu, Giuseppe Ingrasci, Zoe M. Lipman, Keman Zhang, Hong Qiu, Thomas R. Malek, Barbara Bedogni   +12 more
doaj   +2 more sources

Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis [PDF]

Cell Cycle, 2014
Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both tumor-suppressor and oncogenic components. In this study we investigated the effects of reactive oxygen species (ROS) on Notch1 signaling outcome in keratinocyte ...
CHECQUOLO, Saula, MANCA, SONIA, Lello, Zolla, TALORA, Claudio, Angelo, D’Alessandro, BELLAVIA, Diana, UCCELLETTI, Daniela, SCREPANTI, Isabella, VARGAS ROMERO, PAULA ESTEFANIA, PALERMO, ROCCO, SALIOLA, Michele, DE BLASIO, CARLO, CIALFI, Samantha, GULINO, Alberto   +13 more
core   +4 more sources

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Nature Genetics, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis.
E. Abby, S. Dentro, M. Hall, J. Fowler, S. Ong, R. Sood, A. Herms, G. Piedrafita, I. Abnizova, C. Siebel, M. Gerstung, B. A. Hall, P. Jones   +12 more
semanticscholar   +1 more source

Expression of Notch1 in Ameloblastoma and Correlation with CBCT Imaging Subtypes

Central Asian Journal of Medical Sciences, 2023
Objective: Ameloblastoma (AM) is a prevalent benign odontogenic tumor affecting the jaw bone. Its potential for recurrence and malignant transformation is closely associated with the regulation of signaling pathways.
Baoyinbatu Gabiyatu, Wenchao Li, Wurihan, Yuan Tian, Lkhagvasuren Baasandorj, Senhao Li, Sarnai Tsagaankhuu, Damdindorj Boldbaatar   +7 more
doaj   +1 more source

Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims Hepatic immune system disorder plays a critical role in the pathogenesis of acute liver injury. The intrinsic signaling mechanisms responsible for dampening excessive activation of liver macrophages are not completely understood.
Yan Yang, Ming Ni, Ruobin Zong, Mengxue Yu, Yishuang Sun, Jiahui Li, Pu Chen, Changyong Li   +7 more
semanticscholar   +1 more source

Notch1 haploinsufficiency in mice accelerates adipogenesis [PDF]

Scientific Reports, 2021
Abstract Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/−) mice provided with 12-week normal or high-fat diet.
Kazutoshi Yamaguchi, Motoharu Hayashi, Yasuhiro Uchida, Xian Wu Cheng, Takayuki Nakayama, Tadashi Matsushita, Toyoaki Murohara, Kyosuke Takeshita   +7 more
openaire   +3 more sources

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

Nature Communications, 2022
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a ...
Natalia Baran, A. Lodi, Yogesh Dhungana, Shelley M Herbrich, Meghan Collins, Shannon R. Sweeney, R. Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha M Kuruvilla, Antonio Cavazos, Mecit Kaplan, M. Warmoes, Diogo F. T. Veiga, Ken Furudate, Shanti Rojas-Sutterin, A. Haman, Y. Gareau, A. Marinier, Helen Ma, Karine Harutyunyan, May Daher, L. M. Garcia, G. Al-Atrash, Sujan Piya, V. Ruvolo, Wentao Yang, S. Shanmugavelandy, Ningping Feng, J. Gay, Di Du, Jun J. Yang, F. Hoff, Marcin M Kamiński, Katarzyna Tomczak, R. Eric Davis, D. Herranz, A. Ferrando, E. Jabbour, M. Emilia Di Francesco, D. Teachey, T. Horton, S. Kornblau, K. Rezvani, G. Sauvageau, Mihai Gagea, M. Andreeff, Koichi Takahashi, J. Marszalek, P. Lorenzi, Jiyang Yu, S. Tiziani, T. Hoang, M. Konopleva   +54 more
semanticscholar   +1 more source

An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Nature Communications, 2021
Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how Notch signaling is overactivated to couple tumor metastasis and self-renewal in NSCLC cells, we performed the current study and showed that RFC4, a DNA
Lei Liu, Tianyu Tao, Shihua Liu, Xia Yang, Xuwei Chen, Jiaer Liang, Ruohui Hong, Wenting Wang, Yi Yang, Xiao-yin Li, Youhong Zhang, Quanfeng Li, Shujun Liang, Hao Yu, Yun Wu, Xinyu Guo, Yandong Lai, Xiao-Fan Ding, H. Guan, Jueheng Wu, Xun Zhu, Jie Yuan, Jun Li, Shicheng Su, Mengfeng Li, Xiuyu Cai, Junchao Cai, H. Tian   +27 more
semanticscholar   +1 more source

Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency

Circulation Research, 2022
Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic left heart syndrome, where the left ventricle is underdeveloped.
Shiqiao Ye, Cankun Wang, Zhaohui Xu, Hui Lin, X. Wan, Yang Yu, Subhodip Adhicary, Joe Z. Zhang, Yang Zhou, Chun Liu, Matthew Alonzo, Jianli Bi, A. Ramirez‐Navarro, I. Deschênes, Q. Ma, V. Garg, Joseph C. Wu, Ming-Tao Zhao   +17 more
semanticscholar   +1 more source

NOTCH1 signaling regulates the latent neurogenic program in adult reactive astrocytes after spinal cord injury

Theranostics, 2022
Background: Direct reprogramming of astrocytes into neurons opens up a new avenue for neuroregenerative medicine. However, the poor understanding of the molecular mechanisms underpinning the latent neurogenic program in astrocytes has largely restricted ...
Zijian Tan, Shangyao Qin, Yimin Yuan, Xin Hu, Xiao Huang, Hong Liu, Yingyan Pu, Cheng He, Z. Su   +8 more
semanticscholar   +1 more source