Results 11 to 20 of about 110,460 (323)

NOTCH1 is a mechanosensor in adult arteries [PDF]

Nature Communications, 2017
Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity ...
Faas, Guido C, Bouchard, Louis S, Julia J. Mack, Timothy F. Lane, Navab, Mohamad, Mack, Julia J, Fogelman, Alan M, Iruela-Arispe, M Luisa, Su, Trent, Carlos O. Lizama, McDonald, Austin I, Thomas Q. de Aguiar Vallim, Anais Briot, Alan M. Fogelman, Sunshine, Hannah, Yun Fang, Archer, Brian J, Elizabeth J. Tarling, Raquel L. Aragón, Milagros C. Romay, Mohamad Navab, Brian J. Archer, Fang, Yun, Briot, Anais, Lizama, Carlos O, Tarling, Elizabeth J, Kuo, Cheng-Hsiang, Ann C. Zovein, Zovein, Ann C, Louis S. Bouchard, Austin I. McDonald, Cheng-Hsiang Kuo, William M. Jones, Aragón, Raquel L, Trent Su, Jones, William M, Guido C. Faas, Romay, Milagros C, de Aguiar Vallim, Thomas Q, Lane, Timothy F, Mosqueiro, Thiago S, Thiago S. Mosqueiro, M. Luisa Iruela-Arispe, Hannah Sunshine   +43 more
core   +8 more sources

Targetable NOTCH1 rearrangements in reninoma. [PDF]

Nature Communications, 2023
Reninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli.
Tullus, Kjell, Sebire, Neil, Coorens, Tim HH, Mitchell, Thomas J, Anderson, Nathaniel D, Treger, Taryn D, Jones, Philip H, Chowdhury, Tanzina, Oliver, Thomas RW, Young, Matthew D, Pritchard-Jones, Kathy, Lee-Six, Henry, Hutchinson, J Ciaran, Tran, Maxine, Lawrence, John EG, Rampling, Dyanne, Behjati, Sam, Abby, Emilie, Letunovska, Aleksandra, Al-Saadi, Reem, Morcrette, Guillaume   +20 more
core   +10 more sources

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer [PDF]

Nature Cell Biology, 2009
Signalling through Notch receptors requires ligand-induced cleavage to release the intracellular domain, which acts as a transcriptional activator in the nucleus.
Pier Paolo Di Fiore, NUCIFORO P, A. Rosato, TIBERI L, SOLDANO A, P. P. Di Fiore, Paolo Nuciforo, Salvatore Pece, RUSTIGHI A, NAPOLI M, Nuciforo, Paolo, Pece, Salvatore, ROSATO, ANTONIO, DEL SAL G., Di Fiore, Pier Paolo, Marco Napoli, Fred Kaplan, L. Tiberi, Soldano, Alessia, Luca Tiberi, Giannino Del Sal, KAPLAN F, A. Soldano, KAPLAN A, Alessandra Rustighi, NAPOLI, MARCO, P. Nuciforo, DEL SAL, GIANNINO, G. Del Sal, PECE S, A. Capobianco, Alessia Soldano, Capobianco, Anthony, RUSTIGHI, ALESSANDRA, A. Rustighi, ROSATO A, F. Kaplan, Tiberi, Luca, S. Pece, Nuciforo, Paolo Giovanni, Kaplan, Fred, Anthony Capobianco, Antonio Rosato, CAPOBIANCO A, DI FIORE PP, M. Napoli   +45 more
core   +9 more sources

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

Cells, 2020
Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated by the loss of tumor suppressor function ...
Pooja A Shāh, Qiuli Li, Lauren A Byers
exaly   +2 more sources

NOTCH1 Aberrations in Chronic Lymphocytic Leukemia [PDF]

Frontiers in Oncology, 2018
Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly variable clinical outcomes. In recent years, genomic and molecular studies revealed a remarkable heterogeneity in CLL, which mirrored the clinical diversity of ...
Chiara Rompietti, Emanuela Rosati, Stefano Baldoni, Franca Falzetti, Elisa Albi, Beatrice Del Papa, Erica Dorillo, Filomena De Falco, Mauro Di Ianni, Paolo Sportoletti   +9 more
core   +5 more sources

Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties

Cancer Letters, 2018
We have previously shown that Notch1 plays a critical role in modulating melanoma tumor cell growth and survival. Here we show that Notch1 also contributes to an immune-suppressive tumor microenvironment (TME).
Alex Y Huang, David Askew, Barbara Bedogni   +2 more
exaly   +2 more sources

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

PLoS ONE, 2010
BackgroundNotch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms.
Zhang N., Wang H., Fubao Wang, Laurent P Audoly, Audoly, Laurent P, Zhao JZ, Chastain M, Zhang N, Arnold, Beth A, Stephen C Blacklow, Bett AJ, Hongfang Wang, Gu, Mingcheng, Zhang Ningyan, Aster Jon C., Gordon W.R., Sarah L'Heureux, Huber, Hans E, Huber HE, Roti Giovanni, Zhang, Ningyan, Chastain M., Aste-Am閦aga M., Franlin L.L., Aster JC, Blacklow, Stephen C, Toner Timothy J., Haytko P, Baleydier, Frédéric, Chastain Michael, Vo, Kim T, Haytko, Peter, Giovanni Roti, Arnold Beth A., Mingcheng Gu, Bett, Andrew J, Toner T.J., Audoly L.P., Kenneth N Ross, Michael Chastain, Gordon Wendy R., Hui Wang, Franlin Laura L., Zhao Jing Zhang, Arnold BA, Beth A Arnold, Vitelli, Salvatore, Gu Mingcheng, Vitelli Salvatore, Lineberger, Janet E, Ross KN, Lineberger JE, Bett Andrew J., Huang, Lingyi, Toner TJ, Andrawes M.B., Lineberger Janet E., Huang Lingyi, Kittichoat Tiyanont, Haytko Peter, Vitelli S., Timothy J Toner, Aste-Amézaga Miguel, Gordon, Wendy R, Vo K.T., Andrawes MB, Andrawes Marie Blanke, Thoryk E., Wang, Hui, Thoryk, Elizabeth, Andrew J Bett, Wang Hui, Huber H.E., Bett A.J., Peter Haytko, Wendy R Gordon, L'Heureux S, Wang Fubao, Salvatore Vitelli, Marie Blanke Andrawes, Wang, Fubao, Tiyanont, Kittichoat, Huang L., L'Heureux S., Wang F, Blacklow Stephen C., Huang L, Wang H, Miguel Aste-Amézaga, Stegmaier K., Ross Kenneth N., Tiyanont K, Chastain, Michael, L'Heureux Sarah, Gu M, Ross, Kenneth N, Stegmaier K, Kim T Vo, Zhao, Jing Zhang, Baleydier F., Frederic Baleydier, Baleydier Frederic, Laura L Franlin, Lineberger J.E., Roti G., Toner, Timothy J, Andrawes, Marie Blanke, Audoly LP, Arnold B.A., Janet E Lineberger, Hans E Huber, Wang F., Zhao J.Z., Haytko P., L'Heureux, Sarah, Ningyan Zhang, Stegmaier Kimberly, Gu M., Vo Kim T., Aster J.C., Tiyanont K., Audoly Laurent P., Huber Hans E., Baleydier F, Gordon WR, Lingyi Huang, Stegmaier, Kimberly, Jing Zhang Zhao, ROTI, Giovanni, Thoryk Elizabeth, Franlin LL, Jon C Aster, Blacklow S.C., Wang Hongfang, Elizabeth Thoryk, Aste Amézaga M, Franlin, Laura L, Wang, Hongfang, Tiyanont Kittichoat, Vitelli S, Aster, Jon C, Aste-Amézaga, Miguel, Blacklow SC, Ross K.N., Thoryk E, Vo KT, Kimberly Stegmaier   +146 more
core   +7 more sources

Targeting NOTCH1 in hematopoietic malignancy.

Critical Reviews™ in Oncogenesis, 2011
NOTCH1 is a well-validated target in hematopoietic malignancy, with NOTCH1 activating mutations identified in more than 50% of T-cell acute lymphoblastic leukemias.
ROTI, Giovanni, Stegmaier K.
core   +4 more sources

Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

Cancers, 2022
SIMPLE SUMMARY: Mutations of the NOTCH1 gene are a validated prognostic marker in chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based therapies.
Antonella Zucchetto, Tamara Bittolo, Erika Tissino, Zucchetto, Antonella, Valter Gattei, Tanja Nicole Hartmann, Federico Pozzo, Svenja Dannewitz Prosseda, Gattei, Valter, Tissino, Erika, Hartmann, Tanja Nicole, Bomben, Riccardo, Laura Polcik, Dannewitz Prosseda, Svenja, Riccardo Bomben, Polcik, Laura, Pozzo, Federico, Bittolo, Tamara   +17 more
core   +4 more sources

NOTCH1 Mutations Predict Superior Outcomes of Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

ImmunoTargets and Therapy, 2023
Qingyuan Huang,1– 3,* Hang Cao,1– 3,* Qianlan Yao,3– 5,* Xiaoyan Zhou,3– 5 Hang Li,1– 3 Qianming Bai,3– 5 Hong Hu1– 3 1Departments of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China ...
Huang Q, Cao H, Yao Q, Zhou X, Li H, Bai Q, Hu H   +6 more
doaj   +1 more source