Results 81 to 90 of about 110,460 (323)

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

Neural Regeneration Research
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation ...
Yajun Zhu, Xiaoguo Li, Xingwei Lei, Liuyang Tang, Daochen Wen, Bo Zeng, Xiaofeng Zhang, Zichao Huang, Zongduo Guo   +8 more
doaj   +1 more source

Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16^INK4a-Dependent Endothelial Senescence Associated With Atherosclerosis. [PDF]

Aging Cell
CTSL activates Notch1/RBPJ in a ligand‐independent fashion, inducing CUX1/p16INK4a‐dependent endothelial senescence associated with atherosclerosis. ABSTRACT Our post‐GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a‐dependent and atherosclerosis‐associated senescence by indirectly ...
Wu Y, Lu L, Yan S, Du Z, Jiang D, Wu T, Wu Q, Liu J, Ebin J, Sun W, Dutta P, Tan JX, Alder JK, Li G.   +13 more
europepmc   +2 more sources

Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models

, 2014
The Notch1 signaling pathway is essential for hematopoietic development. However, the effects of postnatal activation of Notch1 signaling on hematopoietic system is not yet fully understood. We previously generated ZEG‑IC‑Notch1 transgenic mice that have
Chen, Edwin, Lobe, Corrinne G, Allen, Thaddeus D, Fung, Iris, Dong, Fengyun, Deutsch, Urban, Liu, Ju   +6 more
core   +1 more source

Inhibition of Notch1 reverses EMT and chemoresistance to cisplatin via direct downregulation of MCAM in triple‐negative breast cancer cells

International Journal of Cancer, 2020
Resistance to chemotherapy continues to be a critical issue in the clinical therapy of triple‐negative breast cancer (TNBC). Epithelial–mesenchymal transition (EMT) is thought to contribute to chemoresistance in several cancer types, including breast ...
D. Zeng, Yuan-ke Liang, Yingsheng Xiao, Xiao-Long Wei, Hao-yu Lin, Yang Wu, Jing-Wen Bai, Min Chen, Guo‐Jun Zhang   +8 more
semanticscholar   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells

Frontiers in Oncology, 2018
To investigate chronic lymphocytic leukemia (CLL)-initiating cells, we assessed NOTCH1 mutation/expression in hematopoietic stem cells (HSCs). In NOTCH1-mutated CLL, we detected subclonal mutations in 57% CD34+/CD38− HSCs.
Mauro Di Ianni, Mauro Di Ianni, Stefano Baldoni, Beatrice Del Papa, Patrizia Aureli, Erica Dorillo, Filomena De Falco, Elisa Albi, Emanuela Varasano, Ambra Di Tommaso, Raffaella Giancola, Patrizia Accorsi, Gianluca Rotta, Chiara Rompietti, Estevão Carlos Silva Barcelos, Estevão Carlos Silva Barcelos, Antonio Francesco Campese, Paolo Di Bartolomeo, Isabella Screpanti, Emanuela Rosati, Franca Falzetti, Paolo Sportoletti   +21 more
doaj   +1 more source

Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Journal of Neuroinflammation, 2019
Remote ischemic preconditioning (RIPC) initiates endogenous protective pathways in the brain from a distance and represents a new, promising paradigm in neuroprotection against cerebral ischemia-reperfusion (I/R) injury. However, the underlying mechanism
Weidong Liang, Chunshui Lin, Liuqing Yuan, Li Chen, Pei-pei Guo, Ping Li, Wei Wang, Xin Zhang   +7 more
semanticscholar   +1 more source

The NOTCH1-HEY1 pathway regulates self-renewal and epithelial-mesenchymal transition of salivary adenoid cystic carcinoma cells

International Journal on Biological Sciences, 2020
Our previous study demonstrated a close relationship between the NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). Its receptor gene, NOTCH1, and its downstream gene, HES1, contribute to the proliferation, invasion and metastasis of ...
Jing Xie, Li-Song Lin, Xiao-yu Huang, Rui-huan Gan, Lin-can Ding, Bo-hua Su, Yong Zhao, You-guang Lu, Dali Zheng   +8 more
semanticscholar   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

Haematologica, 2009
Background NOTCH1 mutations have been associated with a favorable outcome in pediatric acute T-lymphoblastic leukemia. However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain ...
Claudia D. Baldus, Julia Thibaut, Nicola Goekbuget, Andrea Stroux, Cornelia Schlee, Max Mossner, Thomas Burmeister, Stefan Schwartz, Clara D. Bloomfield, Dieter Hoelzer, Eckhard Thiel, Wolf-Karsten Hofmann   +11 more
doaj   +1 more source