Results 101 to 110 of about 110,460 (323)

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Journal of experimental & clinical cancer research : CR, 2018
The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling upon immune suppression induced by melanoma ...
Zike Yang, Yanxia Qi, N. Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, R. Luo, Shijun Kang   +8 more
semanticscholar   +1 more source

In Vivo Visualization of Notch1 Proteolysis Reveals the Heterogeneity of Notch1 Signaling Activity in the Mouse Cochlea

PLoS ONE, 2013
Mechanosensory hair cells (HCs) and surrounding supporting cells (SCs) in the mouse cochlea are important for hearing and are derived from the same prosensory progenitors. Notch1 signaling plays dual but contrasting and age-dependent roles in mouse cochlear development: early lateral induction and subsequent lateral inhibition.
Liu, Zhiyong, Liu, Zhenyi, Walters, Bradley J, Owen, Thomas, Kopan, Raphael, Zuo, Jian   +5 more
openaire   +5 more sources

Essential Role of Endothelial Notch1 in Angiogenesis [PDF]

Circulation, 2005
Background— Notch signaling influences binary cell fate decisions in a variety of tissues. The Notch1 receptor is widely expressed during embryogenesis and is essential for embryonic development. Loss of global Notch1 function results in early embryonic lethality, but the cell type responsible for ...
Limbourg, F P, Takeshita, K, Radtke, F, Bronson, R T, Chin, M T, Liao, J K   +5 more
openaire   +2 more sources

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Exosomal miR-182-5p from breast cancer cells reprogram tumor-associated macrophages and promote triple-negative breast cancer progression by targeting Notch1 in macrophages

Archives of Medical Science
Introduction The regulatory role of miR-182 in breast cancer malignancy and macrophage reprogramming is well established. However, the mechanisms through which miR-182 overexpression in tumor cells influences macrophage polarization remain elusive ...
Hongtao Li, Jingjing Fan, Jing Ma, Lei Qiao, Tong Sha, Binlin Ma   +5 more
doaj   +1 more source

An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood.
Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu, Chao Liu   +5 more
doaj   +1 more source

The role of chorionic gonadotropin and Notch1 in implantation [PDF]

Journal of Assisted Reproduction and Genetics, 2007
Failed implantation is a major limiting factor in infertility and early pregnancy loss. In primates, human chorionic gonadotropin mediated inhibition of stromal cell apoptosis and their subsequent differentiation into decidual cells is critical for successful embryo implantation.
Yalda, Afshar, Adina, Stanculescu, Lucio, Miele, Asgerally T, Fazleabas   +3 more
openaire   +2 more sources

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Immunohistochemical results of Notch1.

, 2013
(a) KYSE70 cells with mainly cytoplasmic and membrane staining in most of the cells and a few cells with nuclear staining. (b) a negative Notch1 tumor. (c) normal esophagus epithelial basal cells with cytoplasmic and membrane staining.
Yuanyuan Ma (280707), Dongming Liang (280708), Huijie Fan (280706), Ruixia Huang (280709), Jahn Martin Nesland (280715), Huixiang Li (280714), Karl-Erik Giercksky (76813), Quancheng Kan (280712), Zhenhe Suo (79154), Jian Liu (33711), Fuyou Zhou (280711), Liang Ming (280713), Junsheng Wang (280710)   +12 more
core   +1 more source