Results 121 to 130 of about 110,460 (323)

ROLE OF THE NOTCH1 GENE IN FORMATION OF AORTIC ANEURYSM

Российский кардиологический журнал, 2018
Aim. To evaluate the impact of genetics in development of thoracic aneurysm in patients with tricuspid valve (TAV) and bicuspid aortic valve (BAV) based on the analysis and search for mutations in NOTCH1.Material and methods.
O. V. Irtyuga, O. A. Freilichman, D. S. Krivonosov, A. B. Malashicheva, S. I. Tarnovskaya, V. Е. Uspenskiy, M. L. Gordeev, O. P. Rotar, A. A. Kostareva, O. M. Moiseeva   +9 more
doaj   +1 more source

Notch1ablation radiosensitizes glioblastoma cells [PDF]

Oncotarget, 2017
Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients.
Han, Na, Hu, Guangyuan, Shi, Lei, Long, Guoxian, Yang, Lin, Xi, Qingsong, Guo, Qiuyun, Wang, Jianhua, Dong, Zhen, Zhang, Mengxian   +9 more
openaire   +2 more sources

Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair, Kevin Carratu, Natalie E. Rintoul, Holly L. Hedrick, William H. Peranteau, Catherine M. Avitabile, Kirsty McWalter, Paul Kruszka, Ian D. Krantz, K. Taylor Wild   +9 more
wiley   +1 more source

MODERN VIEWS ON THE GENE NOTCH1 MUTATIONS ROLE FOR AORTIC COARCTATION

Российский кардиологический журнал, 2014
Aim. By the observation of aortic coarctation victims families, to reveal factors predisposing to the disease development, and to evaluate the prevalence of NOTCH1 genes mutation/replacements in patients with this kind of defect.
T. N. Tatarinova, O. A. Freilichman, A. A. Kostareva, E. V. Grekhov, O. M. Moiseeva   +4 more
doaj   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Notch1 Inhibition Exacerbates APAP-Induced Liver Injury via β-Catenin and Macrophage Polarization

Frontiers in Bioscience-Landmark
Background: Notch1 signaling regulates innate immune-mediated inflammation in acute liver injury (ALI). However, the precise mechanism by which Notch1 governs macrophage polarization during ALI remains poorly understood.
Tao Yang, Jingjing Dai, Junlan Zhou, Yuyun Shao, Xiao Wang, Jiaying Zhao, Jun Li, Ping Shi, Longfeng Jiang   +8 more
doaj   +1 more source

Rosuvastatin Improves Neurite Outgrowth of Cortical Neurons against Oxygen-Glucose Deprivation via Notch1-mediated Mitochondrial Biogenesis and Functional Improvement

Frontiers in Cellular Neuroscience, 2018
Neurogenesis, especially neurite outgrowth is an essential element of neuroplasticity after cerebral ischemic injury. Mitochondria may supply ATP to power fundamental developmental processes including neuroplasticity. Although rosuvastatin (RSV) displays
Weiliang He, Yingping Liu, Xiaochao Tian
doaj   +1 more source

Notch1 gene knockdown by siRNA.

, 2013
(A) RT-PCR results of Notch1 in UM cells. OCM1 and VUP cells were analyzed using specific primers for Notch1 mRNA. A 100 bp DNA ladder molecular marker served as the reference. PCR bands were normalized using the internal control β-actin.
Jifan Hu (309999), Guanxiang Qian (130346), Shengfang Ge (130352), Xianqun Fan (130343), Xiaolin Huang (309998), Xiaoping Zhao (130328), He Zhang (130319), Li Wang (15202), Haibo Wang (130324)   +8 more
core   +1 more source

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source

Clinical Value of Differential Expression of Pim1 and Notch1 During Carcinogenesis of Breast Cancer

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the differential expression levels of Pim1 and Notch1 in breast tissues and their clinical and prognostic significance. Methods qRT-PCR, immunohistochemistry and databases were used to detect the mRNA and protein levels of Pim1 ...
XIONG Shishuang, CHEN Xiaowen, MU Ya'nan, ZHANG Derui, JIANG Jinfang, LI Jun, CAO Yuwen   +6 more
doaj   +1 more source