Results 111 to 120 of about 110,460 (323)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

LncRNA DCST1-AS1 Was Upregulated in Endometrial Carcinoma and May Sponge miR-92a-3p to Upregulate Notch1

Cancer Management and Research, 2020
Jieqi Ke, Zheng Shen, Weiping Hu, Min Li, Yangyang Shi, Zhen Xie, Dabao Wu Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui
Ke J, Shen Z, Hu W, Li M, Shi Y, Xie Z, Wu D   +6 more
doaj  

Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase

, 2015
Notch1 is an evolutionarily conserved transmembrane receptor involved in melanoma growth. Notch1 is first cleaved by furin in the Golgi apparatus to produce the biologically active heterodimer.
Keman Zhang, Qiu, Hong, Ma, Jun, Hong Qiu, Khvaramze Shaverdashvili, Jun Ma, Tang, Xiaoying, Bedogni, Barbara, Shaverdashvili, Khvaramze, Xiaoying Tang, Barbara Bedogni, Zhang, Keman   +11 more
core   +1 more source

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL.

Blood, 2019
NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of NOTCH1 mutations.
Viola Close, William L. Close, Sabrina J. Kugler, Michaela Reichenzeller, D. Yosifov, J. Bloehdorn, Leiling Pan, E. Tausch, M. Westhoff, H. Döhner, S. Stilgenbauer, F. Oswald, D. Mertens   +12 more
semanticscholar   +1 more source

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Nature Communications, 2020
Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention.
Atul Katarkar, Giulia Bottoni, A. Clocchiatti, S. Goruppi, Pino Bordignon, F. Lazzaroni, I. Gregnanin, P. Ostano, V. Neel, G. Dotto   +9 more
semanticscholar   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Rehabilitation training improves nerve injuries by affecting Notch1 and SYN

Open Medicine, 2020
The aim of this study was to investigate the effects of rehabilitation training on Notch1 and synaptophysin (SYN) levels in brain tissues of rats with chronic cerebral ischemia.
Jing Mao, Yi Yang, Jinniu Zhang, Xiuli Kan, Jianxian Wu   +4 more
doaj   +1 more source

The putative members of E14 Notch1 and P0 Notch1 gene networks.

, 2015
The putative members of E14 Notch1 and P0 Notch1 gene networks.
Daniel Pelaez (757669), Steve Pappas (757665), Xenia Dvoriantchikova (757668), Ariel Faye Barry (757666), Dagmara Danek (757667), Galina Dvoriantchikova (108911), Isabel Perea-Martinez (244406), Dmitry Ivanov (181301)   +7 more
core   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

NOTCH1 mutation and its prognostic significance in Chinese chronic lymphocytic leukemia: a retrospective study of 317 cases

Cancer Medicine, 2018
The proto‐oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). This study analyzed NOTCH1 mutation status of 317 Chinese patients with CLL by Sanger sequencing. The frequencies of NOTCH1 mutation in the
Yixin Zou, Lei Fan, Yi Xia, Yi Miao, Wei Wu, Lei Cao, Jiazhu Wu, Huayuan Zhu, Chun Qiao, Li Wang, Wei Xu, Jianyong Li   +11 more
doaj   +1 more source