Results 131 to 140 of about 110,460 (323)

Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk

, 2011
The Notch1 receptor is a crucial controller of cell fate decisions, and is also a key regulator of cell growth and differentiation in a variety of contexts.
Ji-Hye Yoon, Ji-Seon Ahn, Hangun Kim, Eun-Jung Ann, Hee-Sae Park, Su-Man Kim, Jane Jung, Hyang-Sook Hoe, Yun-Hee Choi, Jung-Soon Mo, Kwonseop Kim, Hwa-Young Kim, Mi-Yeon Kim   +12 more
core   +1 more source

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

Cellular & Molecular Immunology, 2019
Notch signaling plays important roles in the regulation of immune cell functioning during the inflammatory response. Activation of the innate immune signaling receptor NLRP3 promotes inflammation in injured tissue.
Yuting Jin, Changyong Li, Dongwei Xu, Jian-jun Zhu, Song Wei, Andrew Zhong, M. Sheng, S. Duarte, A. Coito, R. Busuttil, Q. Xia, J. Kupiec-Weglinski, B. Ke   +12 more
semanticscholar   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells

, 2010
Yi-Jang Lee1, Shih-Chieh Hung2–5, Mien-Sheng Chu41Department of Biomedical Imaging and Radiological Sciences, 2Institute of Clinical Medicine, 3Institute of Pharmacology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Stem
Yi-Jang Lee, Shih-Chieh Hung, Mien-Sheng Chu   +2 more
core  

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Diabetic retinopathy is a major cause of blindness in the working population. The most common cause of visual impairment in diabetic patients is diabetic macular edema (DME).
Khalil Miloudi, Malika Oubaha, C. Ménard, A. Dejda, Vera Guber, G. Cagnone, Ariel M. Wilson, N. Tétreault, G. Mawambo, F. Binet, Rony Chidiac, Chantal Delisle, M. Buscarlet, A. Cerani, Sergio Crespo-Garcia, Katie Bentley, F. Rezende, Jean-Sébastien Joyal, Frédérick A. Mallette, J. Gratton, B. Larrivée, P. Sapieha   +21 more
semanticscholar   +1 more source

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions.

Journal of Clinical Endocrinology and Metabolism, 2020
CONTEXT NOTCH signaling is activated in endometriotic lesions, but the exact mechanisms remains unclear. Interleukin-6 (IL-6), which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB
Yong-mei Song, Ren-Wei Su, Niraj R. Joshi, Tae Hoon Kim, B. Lessey, Jae-Wook Jeong, A. Fazleabas   +6 more
semanticscholar   +1 more source

Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili, Paolo Bossi, Luca Lalli, Lisa Francesca Linda Licitra, Marta Maddalo, Almalina Bacigalupo, Liliana Belgioia, Jon Cacicedo, Nadia Facchinetti, Almudena Garcia Castano, Marc Oliva, Pierluigi Bonomo, Giuseppe Sanguineti, Pierfrancesco Franco, Athanassios Argiris, Amanda Psyrri, Ester Orlandi   +16 more
wiley   +1 more source

Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia

, 2014
The purpose of this study was to compare the expression and function of NOTCH1 in chronic lymphocytic leukemia (CLL) patients harboring a wild-type (WT) or mutated NOTCH1 gene.
Coscia M, GIZDIC, BRANIMIR, G. D'Arena, ROSSI, Davide, Arruga F, SERRA, SARA, Laurenti, Luca, DEAGLIO, Silvia, G. Inghirami, VAISITTI, TIZIANA, L. Laurenti, C. Ciardullo, D. Rossi, Serra S, GAIDANO, Gianluca, COSCIA, Marta, Ciardullo C, Jaksic O, Gizdic B, Deaglio S., Vaisitti T, D'Arena G, ARRUGA, Francesca, O. Jaksic, G. Gaidano, Laurenti L, Inghirami G   +26 more
core   +1 more source

Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Diabetic foot ulcerations (DFUs) represent a major medical and economic problem with still-unclear pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, proliferation, and angiogenesis, processes that are ...
Xiaowei Zheng, S. Narayanan, V. Sunkari, Sofie Eliasson, I. Botusan, J. Grünler, A. Catrina, F. Radtke, Cheng-jie Xu, Allan Zhao, N. R. Ekberg, U. Lendahl, S. Catrina   +12 more
semanticscholar   +1 more source

The role of NOTCH1 signaling in T-ALL [PDF]

Hematology, 2009
AbstractThe identification of activating mutations in NOTCH1 in over 50% of T-cell acute lymphoblastic leukemias (T-ALL) has generated major interest in the elucidation of the mechanisms of transformation downstream of oncogenic NOTCH and in the targeting of the NOTCH signaling pathway in this disease. Small molecule γ-secretase inhibitors (GSIs) block
openaire   +2 more sources