Results 151 to 160 of about 110,460 (323)
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.ABSTRACT Background Activating mutations in NOTCH1 are frequent in T‐cell acute lymphoblastic leukemia (T‐ALL) and, in the absence of alterations in RAS or PTEN, are associated with favorable prognosis. Besides classical heterodimerization and PEST domain mutations, juxtamembrane internal tandem duplications (JME‐ITDs) represent a third class of ...
Francisco Beas +8 more
wiley +1 more source
Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells
Frontiers in Immunology, 2019 Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion.
C. Sorrentino +9 more
semanticscholar +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2022 Na Gao,1,* Linghui Xiao,1,* Zheng Tao,2 Yanlin Zheng,1 Wanjie Wang,1 Hui Huang1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2Eye College, Chengdu University of ...
Gao N +5 more
doaj
Histiocytosis development and clinical variation through the lens of genomics
The Journal of Pathology, EarlyView.Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Efficient delivery of Notch1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposome
, 2016 Yun-Chun Zhao,1 Li Zhang,2 Shi-Sen Feng,3 Lu Hong,3 Hai-Li Zheng,3 Li-Li Chen,4 Xiao-Ling Zheng,1 Yi-Qing Ye,1 Meng-Dan Zhao,1 Wen-Xi Wang,3 Cai-Hong Zheng1 1Pharmacy Department, Women’s Hospital, 2Pharmacy Department, The Second Affiliated ...
Hong L +10 more
core
Aryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis
Journal of Inflammation Research, 2021 Kwei-Yan Liu,1 Li-Ting Wang,2 Hsueh-Chun Wang,3,4 Shen-Nien Wang,5– 7 Li-Wen Tseng,5 Chee-Yin Chai,8 Shyh-Shin Chiou,9,10 Shau-Ku Huang,1,11 Shih-Hsien Hsu5,12,13 1Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen ...
Liu KY +8 more
doaj
Notch signaling in the regulation of skeletal muscle stem cells
Journal of Physical Fitness and Sports Medicine, 2018 Resident muscle stem cells are satellite cells that are responsible for the postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In healthy adult muscle, satellite cells are mitotically quiescent, but are activated in response to ...
Shin Fujimaki, Yusuke Ono
doaj +1 more source
The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis
British Journal of Pharmacology, EarlyView.Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan +17 more
wiley +1 more source