Results 141 to 150 of about 110,460 (323)

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1

Open Life Sciences, 2020
Circulating miR-150-5p has been identified as a prognostic marker in patients with critical illness and sepsis. Herein, we aimed to further explore the role and underlying mechanism of miR-150-5p in sepsis.
Deng Xiaoyan, Lin Zhixing, Zuo Chao, Fu Yanjie   +3 more
doaj   +1 more source

Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch

Journal of Neuroinflammation, 2019
BackgroundActivated microglia-mediated neuroinflammation has been regarded as an underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). The therapeutic potential of bone marrow mesenchymal stem cells (
Wenchao Liu, Ran Li, Jia-he Yin, Shenquan Guo, Yunchang Chen, Haiyan Fan, Gancheng Li, Zhenjun Li, Xi-feng Li, Xin Zhang, Xuying He, C. Duan   +11 more
semanticscholar   +1 more source

Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single‐Institution Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and hematogenous spread. Central nervous system (CNS) involvement is uncommon, and detailed clinical and genomic data on this aspect of the disease remain limited.
Omar Elghawy, Jack Stylli, Martin Kurian, Eitan Halper‐Stromberg, Aditi Singh, Christopher D'Avella, Lee Hartner, Roger B. Cohen   +7 more
wiley   +1 more source

SIL-TAL1-Positive Adult T-ALL with t(11;14)(p15;q11.2): A Rare Case Report Highlighting Prognostic Challenges and Treatment Implications

Journal of Inflammation Research
Siyu Chen,1,2,* Shengwang Wu,1,2,* Nan Li,1,2 Xing Qiang,1,2 Yongjie Tang,1,2 Yimei Feng,1,2 Cheng Zhang,1,2 Xiangui Peng,1,2 Shuiqing Liu,1,2 Xi Zhang1– 3 1Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing ...
Chen S, Wu S, Li N, Qiang X, Tang Y, Feng Y, Zhang C, Peng X, Liu S, Zhang X   +9 more
doaj  

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland

Nature Cell Biology, 2018
Recent lineage tracing studies have revealed that mammary gland homeostasis relies on unipotent stem cells. However, whether and when lineage restriction occurs during embryonic mammary development, and which signals orchestrate cell fate specification ...
A. Lilja, V. Rodilla, M. Huyghe, É. Hannezo, Camille Landragin, O. Renaud, O. Leroy, S. Rulands, B. Simons, S. Fre   +9 more
semanticscholar   +1 more source

Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

, 2012
Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH).
Markus H. Heim, Tornillo, Luigi, Radtke, Freddy, Freddy Radtke, Rothweiler, Sonja, Rothweiler, S., Terracciano, L., Meili-Butz, S., Djonov, Valentin, Luigi Terracciano, Silvia Meili–Butz, Tornillo, L., Meili-Butz, Silvia, Dill, M. T., Djonov, V., Luigi Tornillo, Ruslan Hlushchuk, Radtke, F., Hlushchuk, R., Semela, D., Valentin Djonov, Dill, Michael T., Heim, M. H., Dill, Michael T, David Semela, Michael T. Dill, Sonja Rothweiler, Semela, David, Terracciano, Luigi, Hlushchuk, Ruslan, Heim, Markus H., Heim, Markus H   +31 more
core   +1 more source

Missing the notch in NOTCH1 [PDF]

Leukemia & Lymphoma, 2013
Sabrina J, Kugler, Andrea, Schnaiter, Stephan, Stilgenbauer, Daniel, Mertens   +3 more
openaire   +2 more sources

Jagged: A mammalian ligand that activates notch1

Cell, 1995
Here we report the isolation of a rat cDNA clone, Jagged, which we show encodes a ligand for vertebrate Notch. Our conclusion is based on three observations. First, sequence analysis reveals substantial homology between Jagged and invertebrate ligands for the LIN-12/Notch proteins.
Lindsell, Claire E, Shawber, Carrie J, Boulter, Jim, Weinmaster, Gerry   +3 more
openaire   +2 more sources