Results 161 to 170 of about 110,460 (323)

Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide

International Journal of COPD, 2021
Evgenii Skurikhin,1 Olga Pershina,1 Mariia Zhukova,1 Darius Widera,2 Edgar Pan,1 Angelina Pakhomova,1 Vyacheslav Krupin,1 Natalia Ermakova,1 Victoria Skurikhina,3 Lubov Sandrikina,1 Sergey Morozov,4 Aslan Kubatiev,4 Alexander Dygai1,4 1Laboratory of ...
Skurikhin E, Pershina O, Zhukova M, Widera D, Pan E, Pakhomova A, Krupin V, Ermakova N, Skurikhina V, Sandrikina L, Morozov S, Kubatiev A, Dygai A   +12 more
doaj  

Notch1 and Hes1 Crosstabulation.

, 2013
Notch1 and Hes1 Crosstabulation.
Yuanyuan Ma (280707), Dongming Liang (280708), Huijie Fan (280706), Ruixia Huang (280709), Jahn Martin Nesland (280715), Huixiang Li (280714), Karl-Erik Giercksky (76813), Quancheng Kan (280712), Zhenhe Suo (79154), Jian Liu (33711), Fuyou Zhou (280711), Liang Ming (280713), Junsheng Wang (280710)   +12 more
core   +1 more source

Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.

Cancer Letters, 2019
Resistance to chemotherapy remains a significant problem in the treatment of breast cancer, especially for triple-negative breast cancer (TNBC), in which standard systemic therapy is currently limited to chemotherapeutic agents. Our study aimed to better
Yingsheng Xiao, D. Zeng, Yuan-ke Liang, Yang Wu, Meifang Li, Yu-zhu Qi, Xiao-Long Wei, Wen-He Huang, Min Chen, Guo‐Jun Zhang   +9 more
semanticscholar   +1 more source

Altered expression of Notch1 in Alzheimer's disease

PLOS ONE, 2019
Notch signaling is an evolutionarily conserved pathway that regulates cell-cell interactions through binding of Notch family receptors to their cognate ligands. Notch signaling has an essential role in vascular development and angiogenesis. Recent studies have reported that Notch may be implicated in Alzheimer's disease (AD) pathophysiology.
Sun-Jung Cho, Sang-Moon Yun, Chulman Jo, Jihyun Jeong, Moon Ho Park, Changsu Han, Young Ho Koh   +6 more
openaire   +4 more sources

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

hsa-miR-520d-3p and hsa-miR-449a are Candidate MicroRNA Regulators in Multiple Sclerosis [PDF]

Iranian Journal of Medical Sciences
Background: An incapacitating chronic inflammatory neurodegenerative illness, known as multiple sclerosis (MS), is characterized by lymphocyte infiltration into the central nervous system.
Nafiseh Karimi, Majid Motovali Bashi, Mostafa Ghaderi-Zefrehei, Bluma J. Lesch   +3 more
doaj   +1 more source

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry [PDF]

, 2013
Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking.
Dillon, Deborah, Scott Rodig, Mason, Emily F., Morgan, Elizabeth A., Brock, Jane, Brock, Jane E., Daniel J Deangelo, Knoechel, Birgit, Hongfang Wang, Jane E Brock, Krop, Ian E., Stoeck, Alexander, Leigh, Irene M., Chirieac, Lucian, Aster, Jon C., Cassidy, Andrew J., Morgan, Elizabeth, David Dorfman, South, Andrew P., David M Weinstock, Cho, Raymond J., Brian B Haines, Sriram Sathayanrayanan, Dorfman, David, Chirieac, Lucian R., Hornick, Jason, Alexander J F Lazar, Lazar, Alexander J. F., Myron Peto, Kluk, Michael J., Irene M Leigh, Celine Pourreyron, Lucian R Chirieac, Deborah Dillon, Pinkus, Geraldine, Ian E Krop, Weigert, Oliver, Aster, Jon, Geraldine Pinkus, Raymond J Cho, Alexander Stoeck, Sathayanrayanan, Sriram, DeAngelo, Daniel J., Ashworth, Todd, Andrew P South, Hornick, Jason L., Hirsch, Michelle, Jason L Hornick, Birgit Knoechel, Oh, David J., Michelle Hirsch, Jon C Aster, Pourreyron, Celine, Weinstock, David M., Emily F Mason, Wang, Hongfang, Andrew J Cassidy, David J Oh, Michael J Kluk, Elizabeth A Morgan, Oliver Weigert, Todd Ashworth, Peto, Myron, Rodig, Scott, Haines, Brian B.   +64 more
core   +1 more source

Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Malignant transformation is known to occur with many nevi, such as nevus sebaceus. However, cases of secondary tumors developing in an epidermal nevus (EN) are rare, with only a few case reports documented in the literature. We present three unique cases of syringocystadenoma papilliferum (SCAP), syringofibroadenoma, trichilemmoma, and basal ...
Haya A. Homsi, Melissa Piliang, Jennifer Lucas, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source