Results 91 to 100 of about 110,460 (323)
, 2013 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Recently, recurrent activating mutations of NOTCH1 have been reported in up to 12% of CLL patients, underlining the relevance of NOTCH1 mutations (NOTCH1mut) as an independent ...
Grossmann, Vera +11 more
core +1 more source
Notch1 Mutations Are Drivers of Oral Tumorigenesis [PDF]
Cancer Prevention Research, 2015 Abstract Disruption of NOTCH1 signaling was recently discovered in head and neck cancer. This study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell carcinoma (OSCC) and compare the occurrence of these mutations in Chinese and Caucasian populations.
Evgeny, Izumchenko +11 more
openaire +2 more sources
Mechanisms of Pericyte‐Mediated Cancer Metastasis
Advanced Science, EarlyView.Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley +1 more source
Фундаментальная и клиническая медицина, 2018 Aim. Bioprosthetic mitral valves frequently undergo severe calcification causing bioprosthetic valve failure, an urgent problem in cardiovascular surgery.
ANASTASIA V. Ponasenko +7 more
doaj
International Journal of COPD, 2020 Jun Luo,1,* Li Li,2,* Die Hu,2 Xian Zhang1 1Department of Laboratory Medicine, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Dujiangyan People ...
Luo J, Li L, Hu D, Zhang X
doaj
Journal of Experimental & Clinical Cancer Research, 2019 Background NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5–10% of cases and are associated with significantly shorter survival rates.
Elisabeth Silkenstedt +14 more
doaj +1 more source
Advanced Science, EarlyView.Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong +4 more
wiley +1 more source
BMC Neurology, 2018 Background Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However, the role of Notch1 in glioma EMT
Jianlong Li +7 more
doaj +1 more source
, 2015 To investigate if flow is required for the expression of Notch1, we stained for Notch1 expression in embryos in which had ablated flow. Notch1 expression is present in the dorsal aorta of the control embryos (E, n=4) but no expression is observed in ...
Elizabeth Jones (679862)
core +1 more source
Lack of requirement for Presenilin1 in Notch1 signaling [PDF]
Current Biology, 1999 Studies in invertebrates have indicated a functional requirement for presenilin (PS) genes in the Notch pathway [1-5]. One model of Notch signal transduction suggests that proteolysis releases an activated Notch fragment that migrates to the nucleus and regulates gene transcription in concert with CBF1/Su(H)/lag1 (CSL) proteins [6-9].
Berechid, B.E +4 more
openaire +2 more sources