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Biological Significance of NOTCH Signaling Strength
Frontiers in Cell and Developmental Biology, 2021 The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
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Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
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The Notch signaling pathway: a potential target for cancer immunotherapy
Journal of Hematology & Oncology, 2023 Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation.
Xinxin Li +5 more
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Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
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Frontiers in Genetics, 2021 Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Fengchao Zhang +3 more
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To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis
Biomolecules, 2021 Notch signaling forms an evolutionarily conserved juxtacrine pathway crucial for cellular development. Initially identified in Drosophila wing morphogenesis, Notch signaling has since been demonstrated to play pivotal roles in governing mammalian ...
Han Leng Ng +3 more
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Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells
Frontiers in Cell and Developmental Biology, 2022 Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling.
Cansu Karakaya +12 more
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Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
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The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
Medicines, 2018 There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC.
Adriana Harbuzariu +2 more
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Non-Canonical Notch Signaling in Cancer and Immunity
Frontiers in Oncology, 2014 Canonical Notch signaling is initiated by -secretase mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-J, resulting in the activation of ...
Barbara A Osborne, Furkan eAyaz
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