Results 11 to 20 of about 110,123 (264)
Notch Signaling and Alloreactivity [PDF]
Transplantation, 2016 Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-host disease remain major obstacles
Vedran, Radojcic, Ivan, Maillard
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NOTCH Signaling in Osteosarcoma
Current Issues in Molecular Biology, 2023 The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective.
Zhenhao Zhang, Wei Wu, Zengwu Shao
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Notch Signaling in Cancer [PDF]
Cancer Biology & Therapy, 2002 Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant ...
Allenspach, Eric J +3 more
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Notch Signaling in Leukemia [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2007 Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this ...
Jon C, Aster +2 more
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Notch signaling at a glance [PDF]
Journal of Cell Science, 2013 Cell–cell interactions define a quintessential aspect of multicellular development. Metazoan morphogenesis depends on a handful of fundamental, conserved cellular interaction mechanisms, one of which is defined by the Notch signaling pathway. Signals transmitted through the Notch surface receptor have a unique developmental role: Notch signaling links ...
Kazuya, Hori +2 more
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Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
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EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1
Scientific Reports, 2023 Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans that regulate Notch signaling.
Mohd Nauman +4 more
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Journal of Cardiovascular Development and Disease, 2021 The Notch intercellular signaling pathways play significant roles in cardiovascular development, disease, and regeneration through modulating cardiovascular cell specification, proliferation, differentiation, and morphogenesis. The dysregulation of Notch
Angello Huerta Gomez +5 more
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Notch Signaling and the Skeleton [PDF]
Endocrine Reviews, 2016 Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch signaling plays an important role in skeletal development and bone remodeling. After direct interactions with ligands of the Jagged and Delta-like families, a series of cleavages release the Notch intracellular domain (NICD), which translocates to the nucleus where ...
Stefano, Zanotti, Ernesto, Canalis
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Scientific Reports, 2022 To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors.
Bhairavi Swaminathan +10 more
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