Results 11 to 20 of about 133,611 (360)
Biological Significance of NOTCH Signaling Strength
Frontiers in Cell and Developmental Biology, 2021 The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
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Cells, 2020 Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA).
Esra’a Keewan, Saleh A. Naser
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Non-small-cell lung carcinoma: role of the Notch signaling pathway
Lung Cancer: Targets and Therapy, 2015 Levi Barse, Maurizio Bocchetta Department of Pathology, Oncology Institute, Loyola University Chicago, Maywood, IL, USA Abstract: Notch signaling plays a pivotal role during embryogenesis.
Barse L, Bocchetta M
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Notch Signaling In Solid Tumors
, 2010 In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer.
Koch, Ute, Radtke, Freddy
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Notch signaling in the brain: In good and bad times
Ageing Research Reviews, 2013 Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating ...
Lavinia Alberi, Emanuele Brai
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Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
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The Notch signaling pathway: a potential target for cancer immunotherapy
Journal of Hematology & Oncology, 2023 Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation.
Xinxin Li +5 more
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Notch Signaling and Alloreactivity [PDF]
Transplantation, 2016 Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-host disease remain major obstacles
Vedran, Radojcic, Ivan, Maillard
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NOTCH Signaling in Osteosarcoma
Current Issues in Molecular Biology, 2023 The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective.
Zhenhao Zhang, Wei Wu, Zengwu Shao
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Notch Signaling in Cancer [PDF]
Cancer Biology & Therapy, 2002 Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant ...
Allenspach, Eric J +3 more
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