Results 41 to 50 of about 983,789 (303)
Biomolecules, 2022 Endoplasmic reticulum (ER) stress activated in granulosa cells contributes to the pathophysiology of polycystic ovary syndrome (PCOS). In addition, recent studies have demonstrated that Notch signaling plays multiple roles in the ovary via cell-to-cell ...
Hiroshi Koike +12 more
doaj +1 more source
Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]
, 2005 In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core +1 more source
Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
doaj +1 more source
Notch Signaling in the Vasculature [PDF]
, 2010 Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include the regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells, regulation of blood vessel sprouting and ...
openaire +2 more sources
The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]
, 2004 The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
core +2 more sources
Regulation of the self-renewal vs. differentiation decision in the C.elegans germline [PDF]
, 2011 Adult stem cells are the basis of our reproductive potential, of tissue growth and maintenance, and of wound healing and regeneration. Ageing phenotypes such as hair loss or brittle bones in fact reflect the gradual decline of the proliferative ...
Kalchhauser, Irene
core +1 more source
Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]
, 2013 The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn +25 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Role of Notch signaling in the mammalian heart
Brazilian Journal of Medical and Biological Research, 2014 Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
doaj +1 more source