Results 51 to 60 of about 110,123 (264)

Notch Signaling in B Cell Immune Responses

Frontiers in Immunology, 2021
The Notch signaling pathway is highly evolutionarily conserved, dictating cell fate decisions and influencing the survival and growth of progenitor cells that give rise to the cells of the immune system. The roles of Notch signaling in hematopoietic stem
Matthew Garis, Lee Ann Garrett-Sinha
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Competition in notch signaling with cis enriches cell fate decisions.

PLoS ONE, 2014
Notch signaling is involved in cell fate choices during the embryonic development of Metazoa. Commonly, Notch signaling arises from the binding of the Notch receptor to its ligands in adjacent cells driving cell-to-cell communication.
Pau Formosa-Jordan, Marta Ibañes
doaj   +1 more source

Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer

BMC Cancer, 2022
Background The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for ...
Fei Wang, Chuan Huang, Jie Long, Zhi-Bin Zhao, Hai-Qing Ma, Xue-Qing Yao, Liang Li, Zhe-Xiong Lian   +7 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask

Cell Communication and Signaling
Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer

Frontiers in Nutrition
The Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. The dual role of Notch signaling is significant. It can promote or inhibit cancer progression depending
Rong-Zu Nie, Rong-Zu Nie, Hang Wang, Hang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Huo-Min Luo, Huo-Min Luo, Chen Chen, Chen Chen, Zhao-Hui Jing, Zhao-Hui Jing, Pei-Feng Li, Pei-Feng Li   +13 more
doaj   +1 more source

Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development

Frontiers in Immunology, 2018
SIRT1 is reported to participate in macrophage differentiation and affect sepsis, and Notch signaling is widely reported to influence inflammation and macrophage activation.
Xiaozhi Bai, Ting He, Yang Liu, Julei Zhang, Xiaoqiang Li, Jihong Shi, Kejia Wang, Fu Han, Wei Zhang, Yijie Zhang, Weixia Cai, Dahai Hu   +11 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source