Results 51 to 60 of about 983,789 (303)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Signal Transduction and Targeted TherapyNotch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi +9 more
doaj +1 more source
A role for actomyosin contractility in Notch signaling
BMC Biology, 2019 Background Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition.
Ginger L. Hunter +5 more
doaj +1 more source
Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. [PDF]
PLoS Genetics, 2014 Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood.
Chen-Yuan Tseng +5 more
doaj +1 more source
Notch1 signaling in the hepatic microcirculation and chronic liver disease [PDF]
, 2013 The Notch signaling pathway is an evolutionary conserved pathway that plays essential roles during vascular development and in the regulation of normal and pathological angiogenesis in the adulthood.
Rothweiler, Sonja
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MPDZ promotes DLL4-induced Notch signaling during angiogenesis
eLife, 2018 Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions.
Fabian Tetzlaff +7 more
doaj +1 more source
Involvement of notch signaling in wound healing. [PDF]
PLoS ONE, 2007 The Notch signaling pathway is critically involved in cell fate decisions during development of many tissues and organs. In the present study we employed in vivo and cell culture models to elucidate the role of Notch signaling in wound healing.
Srinivasulu Chigurupati +14 more
doaj +1 more source